Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide
Acrylamide (ACR) is among the most deleterious pollutants in the environment and presents a serious risk to humans and ecosystems. The purpose of this study was to assess its effects when administered at different concentrations (5, 10 and 20 mg L–1) to evaluate antioxidant status in the gills of Ma...
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2020-06-01
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doaj-b1215dc5bc15470185049c3194a01fa82021-05-05T13:49:32ZengConsejo Superior de Investigaciones CientíficasScientia Marina0214-83581886-81342020-06-0184214315010.3989/scimar.04993.11A1818Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamideWafa Trabelsi0https://orcid.org/0000-0002-1114-4080Chaima Fouzai1https://orcid.org/0000-0001-7588-1859Imene Chetoui2https://orcid.org/0000-0002-2259-5397Safa Bejaoui3https://orcid.org/0000-0002-7946-2763Khaoula Telahigue4https://orcid.org/0000-0001-8841-9911Imen Rabeh5https://orcid.org/0000-0002-0307-473XMhamed El Cafsi6https://orcid.org/0000-0002-9771-1110Nejla Soudani7https://orcid.org/0000-0002-7652-9678Laboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisLaboratory of Ecology, Biology and Physiology of Aquatic Organisms, Department of Biology, Tunis Faculty of Sciences, Univ. TunisAcrylamide (ACR) is among the most deleterious pollutants in the environment and presents a serious risk to humans and ecosystems. The purpose of this study was to assess its effects when administered at different concentrations (5, 10 and 20 mg L–1) to evaluate antioxidant status in the gills of Mactra stultorum. Our results showed, after five days of treatment, an increase in malondialdehyde (MDA), lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), reduced glutathione (GSH), ascorbic acid (Vit C) and metallothionein (MDA) levels in gills of treated clams compared with controls. Moreover, an increase in superoxide dismutase (SOD) and a significant decrease in glutathione peroxidase (GPx) activities were also observed. Acrylamide induced neurotoxicity, as evidenced by the inhibition of acetylcholinesterase (AChE) activity in a dose-dependent manner. Overall, our results indicated that oxidative stress may be considered one of the mechanisms behind acrylamide toxicity in bivalves, although the subject requires more research.http://scientiamarina.revistas.csic.es/index.php/scientiamarina/article/view/1858acrylamideexposuremactra stultorumgillsantioxidant statusacetylcholinesterase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wafa Trabelsi Chaima Fouzai Imene Chetoui Safa Bejaoui Khaoula Telahigue Imen Rabeh Mhamed El Cafsi Nejla Soudani |
spellingShingle |
Wafa Trabelsi Chaima Fouzai Imene Chetoui Safa Bejaoui Khaoula Telahigue Imen Rabeh Mhamed El Cafsi Nejla Soudani Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide Scientia Marina acrylamide exposure mactra stultorum gills antioxidant status acetylcholinesterase |
author_facet |
Wafa Trabelsi Chaima Fouzai Imene Chetoui Safa Bejaoui Khaoula Telahigue Imen Rabeh Mhamed El Cafsi Nejla Soudani |
author_sort |
Wafa Trabelsi |
title |
Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide |
title_short |
Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide |
title_full |
Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide |
title_fullStr |
Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide |
title_full_unstemmed |
Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide |
title_sort |
oxidative stress biomarkers in the gills of the bivalve mactra stultorum exposed to acrylamide |
publisher |
Consejo Superior de Investigaciones Científicas |
series |
Scientia Marina |
issn |
0214-8358 1886-8134 |
publishDate |
2020-06-01 |
description |
Acrylamide (ACR) is among the most deleterious pollutants in the environment and presents a serious risk to humans and ecosystems. The purpose of this study was to assess its effects when administered at different concentrations (5, 10 and 20 mg L–1) to evaluate antioxidant status in the gills of Mactra stultorum. Our results showed, after five days of treatment, an increase in malondialdehyde (MDA), lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), reduced glutathione (GSH), ascorbic acid (Vit C) and metallothionein (MDA) levels in gills of treated clams compared with controls. Moreover, an increase in superoxide dismutase (SOD) and a significant decrease in glutathione peroxidase (GPx) activities were also observed. Acrylamide induced neurotoxicity, as evidenced by the inhibition of acetylcholinesterase (AChE) activity in a dose-dependent manner. Overall, our results indicated that oxidative stress may be considered one of the mechanisms behind acrylamide toxicity in bivalves, although the subject requires more research. |
topic |
acrylamide exposure mactra stultorum gills antioxidant status acetylcholinesterase |
url |
http://scientiamarina.revistas.csic.es/index.php/scientiamarina/article/view/1858 |
work_keys_str_mv |
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