Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks.
Once biological systems are modeled by regulatory networks, the next step is to include external stimuli, which model the experimental possibilities to affect the activity level of certain network's nodes, in a mathematical framework. Then, this framework can be interpreted as a mathematical op...
Main Authors: | Tim Breitenbach, Chunguang Liang, Niklas Beyersdorf, Thomas Dandekar |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-07-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1007075 |
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