Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.
Gammaherpesviruses encode proteins with homology to the cellular purine metabolic enzyme formyl-glycinamide-phosphoribosyl-amidotransferase (FGARAT), but the role of these viral FGARATs (vFGARATs) in the pathogenesis of a natural host has not been investigated. We report a novel role for the ORF75A...
Main Authors: | Nick D Van Skike, Nana K Minkah, Chad H Hogan, Gary Wu, Peter T Benziger, Darby G Oldenburg, Mehmet Kara, Deborah M Kim-Holzapfel, Douglas W White, Scott A Tibbetts, Jarrod B French, Laurie T Krug |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-02-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5811070?pdf=render |
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