Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

Abstract Background Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC. This study aimed to explore the effects of PKM2 on global gene expression, metabolic damages, patient prognosis,...

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Bibliographic Details
Main Authors: Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian, Wen-Xing Li
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
PKM2
Metabolic
Overall survival
Drugs
Online Access:http://link.springer.com/article/10.1186/s12885-018-5023-0

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