Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

Summary: Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding site on viral spike receptor-binding domains (RBDs). Potent antibodies recognize exposed variable epitopes, often rendering them inef...

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Bibliographic Details
Main Authors: Claudia A. Jette, Alexander A. Cohen, Priyanthi N.P. Gnanapragasam, Frauke Muecksch, Yu E. Lee, Kathryn E. Huey-Tubman, Fabian Schmidt, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig, Anthony P. West, Jr., Jennifer R. Keeffe, Pamela J. Bjorkman, Christopher O. Barnes
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
cryo-EM
coronavirus
neutralizing antibody
receptor-binding domain
sarbecovirus
SARS-CoV-2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012146

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