Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy
Objective: To compare the conjunctival morphological changes in patients with Hashimoto�s thyroiditis (HT) without thyroid-associated ophthalmopathy (TAO) and controls using impression cytology technique. Material and Method: We included 25 HT patients and 33 healthy controls who did not have TAO f...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Federation of Turkish Pathology Societies
2019-09-01
|
Series: | Türk Patoloji Dergisi |
Subjects: | |
Online Access: |
http://www.turkjpath.org/pdf.php3?id=1898
|
id |
doaj-b1502f5a8d4645dc8c32be558cb42b06 |
---|---|
record_format |
Article |
spelling |
doaj-b1502f5a8d4645dc8c32be558cb42b062020-11-25T02:08:45ZengFederation of Turkish Pathology SocietiesTürk Patoloji Dergisi1018-56151309-57302019-09-0135321322010.5146/tjpath.2019.01461Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated OphthalmopathyMustafa ALTAYTuğba ŞAHİNZennure YILDIZGülçin ŞİMŞEKMehmet ÇITIRIKİhsan ATEŞMurat DAĞDEVİRENMuharrem BİTİRENObjective: To compare the conjunctival morphological changes in patients with Hashimoto�s thyroiditis (HT) without thyroid-associated ophthalmopathy (TAO) and controls using impression cytology technique. Material and Method: We included 25 HT patients and 33 healthy controls who did not have TAO findings or dry eye. For both groups, thyroid stimulating hormone (TSH), free T4(FT4), and anti-thyroid peroxidase (anti-TPO) were measured. Thyroid ultrasonography was performed, together with all routine eye check-ups and the Schirmer's test. Also, conjunctival impression cytology (CIC) test was performed to analyze the conjunctival morphology. Results: When the CIC of HT patients was observed; 12% had grade 0, 40% had grade 1, 28% had grade 2 and 20% had grade 3. While patients with squamous metaplasia made up 48% of the HT group, this was observed at 6.1% in the control group (p < 0,001). In the regression model formulated, it was observed that obesity (OR=7.500; p=0.017) and anti TPO levels (OR=1.370, p=0,007) were independent stipulations for the squamous metaplasia. Conclusion: Conjunctival squamous metaplasia was more frequently seen in HT than controls and serum Anti-TPO level and obesity were detected as independent predictors of the worsening at the conjunctival impression cytology. http://www.turkjpath.org/pdf.php3?id=1898 Anti-TPOConjunctival impression cytologyHashimoto's thyroiditisInflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mustafa ALTAY Tuğba ŞAHİN Zennure YILDIZ Gülçin ŞİMŞEK Mehmet ÇITIRIK İhsan ATEŞ Murat DAĞDEVİREN Muharrem BİTİREN |
spellingShingle |
Mustafa ALTAY Tuğba ŞAHİN Zennure YILDIZ Gülçin ŞİMŞEK Mehmet ÇITIRIK İhsan ATEŞ Murat DAĞDEVİREN Muharrem BİTİREN Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy Türk Patoloji Dergisi Anti-TPO Conjunctival impression cytology Hashimoto's thyroiditis Inflammation |
author_facet |
Mustafa ALTAY Tuğba ŞAHİN Zennure YILDIZ Gülçin ŞİMŞEK Mehmet ÇITIRIK İhsan ATEŞ Murat DAĞDEVİREN Muharrem BİTİREN |
author_sort |
Mustafa ALTAY |
title |
Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy |
title_short |
Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy |
title_full |
Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy |
title_fullStr |
Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy |
title_full_unstemmed |
Changes in Conjunctiva Morphology Using Impression Cytology in Patients with Hashimoto's Thyroiditis without Thyroid-Associated Ophthalmopathy |
title_sort |
changes in conjunctiva morphology using impression cytology in patients with hashimoto's thyroiditis without thyroid-associated ophthalmopathy |
publisher |
Federation of Turkish Pathology Societies |
series |
Türk Patoloji Dergisi |
issn |
1018-5615 1309-5730 |
publishDate |
2019-09-01 |
description |
Objective: To compare the conjunctival morphological changes in patients with Hashimoto�s thyroiditis (HT) without thyroid-associated ophthalmopathy (TAO) and controls using impression cytology technique.
Material and Method: We included 25 HT patients and 33 healthy controls who did not have TAO findings or dry eye. For both groups, thyroid stimulating hormone (TSH), free T4(FT4), and anti-thyroid peroxidase (anti-TPO) were measured. Thyroid ultrasonography was performed, together with all routine eye check-ups and the Schirmer's test. Also, conjunctival impression cytology (CIC) test was performed to analyze the conjunctival morphology.
Results: When the CIC of HT patients was observed; 12% had grade 0, 40% had grade 1, 28% had grade 2 and 20% had grade 3. While patients with squamous metaplasia made up 48% of the HT group, this was observed at 6.1% in the control group (p < 0,001). In the regression model formulated, it was observed that obesity (OR=7.500; p=0.017) and anti TPO levels (OR=1.370, p=0,007) were independent stipulations for the squamous metaplasia.
Conclusion: Conjunctival squamous metaplasia was more frequently seen in HT than controls and serum Anti-TPO level and obesity were detected as independent predictors of the worsening at the conjunctival impression cytology. |
topic |
Anti-TPO Conjunctival impression cytology Hashimoto's thyroiditis Inflammation |
url |
http://www.turkjpath.org/pdf.php3?id=1898
|
work_keys_str_mv |
AT mustafaaltay changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT tugbasahin changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT zennureyildiz changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT gulcinsimsek changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT mehmetcitirik changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT ihsanates changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT muratdagdeviren changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy AT muharrembitiren changesinconjunctivamorphologyusingimpressioncytologyinpatientswithhashimotosthyroiditiswithoutthyroidassociatedophthalmopathy |
_version_ |
1724925598793465856 |