Intravitreous Delivery of Αb-Crystallin Ameliorates N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration in Mice: An in vivo and ex vivo Study

Intravitreous Delivery of Αb-Crystallin Ameliorates N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration in Mice: An in vivo and ex vivo Study

Background/Aims: αB –crystallin (αBC) belongs to the family of small heat shock proteins that are necessary for maintaining oxygen homeostasis. This study was designed to explore the possible effects of αBC on N-methyl- N-nitrosourea (MNU) induced retinal degeneration and the underlying mechanisms....

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Bibliographic Details
Main Authors: Ye Tao, Lei Ding, Anhui Yao, Zhen Yang, Qinghua Yang, Limin Qin, Linjun Yu, Yanling Gao, Yi Fei Huang, Zhengwei Li, Dengke Teng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Retinitis pigmentosa
Photoreceptor
Apoptosis
Crystallin
Online Access:https://www.karger.com/Article/FullText/492557

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