N-3 polyunsaturated acids in erythrocyte phospholipids are associated with insulin sensitivity in obese patients on a typical Serbian diet

N-3 polyunsaturated acids in erythrocyte phospholipids are associated with insulin sensitivity in obese patients on a typical Serbian diet

This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitiv­ity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well a...

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Bibliographic Details
Main Authors: Takić Marija, Ristić-Medić Danijela, Mandić Ljuba, Glibetić Marija, Arsić Aleksandra, Debeljak-Martačić Jasmina, Ristić-Oddiano Gordana
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2009-01-01
Series:Archives of Biological Sciences
Subjects:
n-3 PUFA
insulin resistance
obesity
hyperlipidemia
dietary fat
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640901037T.pdf
Description
Summary:This study examines the relationship between erythrocyte phospholipid FA composition and insulin sensitiv­ity in obese patients on a typical Serbian diet. In 30 patients, two insulin sensitivity groups were formed and their FAs analyzed. The shares of 22:5n-3, 22:6n-3, and total n-3 PUFAs, as well as a measure of Δ5 desaturase activity (the 20:4n-6/20:3n-6 ratio) were lower in the insulin resistance group compared to the normal glucose tolerance group. The fasting insulin level and HOMA value were inversely related to the percentage of 22:5n-3, 22:6n-3, and total n-3 PUFAs. Our data indicate that the percentage of n-3 PUFAs in erythrocyte phospholipids is linked with insulin sensitivity parameters in obese patients.
ISSN:0354-4664

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