Transforming growth factor β<sub>1 </sub>inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?
<p>Abstract</p> <p>Background</p> <p>Bone morphogenic proteins (BMPs) play a key role in bone formation. Consequently, it was expected that topical application of recombinant human (rh)BMP-2 and rhBMP-7 would improve the healing of complex fractures. However, up to 36%...
Main Authors: | Ehnert Sabrina, Zhao Jian, Pscherer Stefan, Freude Thomas, Dooley Steven, Kolk Andreas, Stöckle Ulrich, Nussler Andreas, Hube Robert |
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Format: | Article |
Language: | English |
Published: |
BMC
2012-09-01
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Series: | BMC Medicine |
Subjects: | |
Online Access: | http://www.biomedcentral.com/1741-7015/10/101 |
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