N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
Bibliographic Details
| Main Authors: |
Ri-Xin Chen,
Xin Chen,
Liang-Ping Xia,
Jia-Xing Zhang,
Zhi-Zhong Pan,
Xiao-Dan Ma,
Kai Han,
Jie-Wei Chen,
Jean-Gabrie Judde,
Olivier Deas,
Feng Wang,
Ning-Fang Ma,
Xinyuan Guan,
Jing-Ping Yun,
Feng-Wei Wang,
Rui-Hua Xu,
Dan Xie |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-12651-2
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