N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.

Bibliographic Details
Main Authors: Ri-Xin Chen, Xin Chen, Liang-Ping Xia, Jia-Xing Zhang, Zhi-Zhong Pan, Xiao-Dan Ma, Kai Han, Jie-Wei Chen, Jean-Gabrie Judde, Olivier Deas, Feng Wang, Ning-Fang Ma, Xinyuan Guan, Jing-Ping Yun, Feng-Wei Wang, Rui-Hua Xu, Dan Xie
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12651-2
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spelling doaj-b165c50eadf6469b96c3526cdacb8a2b2021-05-11T11:49:35ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12651-2N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasisRi-Xin Chen0Xin Chen1Liang-Ping Xia2Jia-Xing Zhang3Zhi-Zhong Pan4Xiao-Dan Ma5Kai Han6Jie-Wei Chen7Jean-Gabrie Judde8Olivier Deas9Feng Wang10Ning-Fang Ma11Xinyuan Guan12Jing-Ping Yun13Feng-Wei Wang14Rui-Hua Xu15Dan Xie16State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterXenTech SASXenTech SASState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterKey Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical UniversityState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterLiver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.https://doi.org/10.1038/s41467-019-12651-2
collection DOAJ
language English
format Article
sources DOAJ
author Ri-Xin Chen
Xin Chen
Liang-Ping Xia
Jia-Xing Zhang
Zhi-Zhong Pan
Xiao-Dan Ma
Kai Han
Jie-Wei Chen
Jean-Gabrie Judde
Olivier Deas
Feng Wang
Ning-Fang Ma
Xinyuan Guan
Jing-Ping Yun
Feng-Wei Wang
Rui-Hua Xu
Dan Xie
spellingShingle Ri-Xin Chen
Xin Chen
Liang-Ping Xia
Jia-Xing Zhang
Zhi-Zhong Pan
Xiao-Dan Ma
Kai Han
Jie-Wei Chen
Jean-Gabrie Judde
Olivier Deas
Feng Wang
Ning-Fang Ma
Xinyuan Guan
Jing-Ping Yun
Feng-Wei Wang
Rui-Hua Xu
Dan Xie
N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
Nature Communications
author_facet Ri-Xin Chen
Xin Chen
Liang-Ping Xia
Jia-Xing Zhang
Zhi-Zhong Pan
Xiao-Dan Ma
Kai Han
Jie-Wei Chen
Jean-Gabrie Judde
Olivier Deas
Feng Wang
Ning-Fang Ma
Xinyuan Guan
Jing-Ping Yun
Feng-Wei Wang
Rui-Hua Xu
Dan Xie
author_sort Ri-Xin Chen
title N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_short N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_full N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_fullStr N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_full_unstemmed N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_sort n 6-methyladenosine modification of circnsun2 facilitates cytoplasmic export and stabilizes hmga2 to promote colorectal liver metastasis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
url https://doi.org/10.1038/s41467-019-12651-2
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