Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity
Oxytocin (OXT) is known to play an important role in trust, whereas the involvement of other peptide hormones has not been evaluated. In this study, we focused on microsatellite polymorphisms in the intron of the arginine-vasopressin receptor 1a (AVPR1a) gene and examined whether the association bet...
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Frontiers Media S.A.
2019-07-01
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doaj-b1671b0d760f419f86a72c721cf20fa52020-11-25T02:09:59ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-07-011310.3389/fnhum.2019.00230456789Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and ReciprocityKuniyuki Nishina0Haruto Takagishi1Hidehiko Takahashi2Masamichi Sakagami3Miho Inoue-Murayama4Graduate School of Brain Sciences, Tamagawa University, Tokyo, JapanBrain Science Institute, Tamagawa University, Tokyo, JapanGraduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanBrain Science Institute, Tamagawa University, Tokyo, JapanWildlife Research Center, Kyoto University, Kyoto, JapanOxytocin (OXT) is known to play an important role in trust, whereas the involvement of other peptide hormones has not been evaluated. In this study, we focused on microsatellite polymorphisms in the intron of the arginine-vasopressin receptor 1a (AVPR1a) gene and examined whether the association between the repeat lengths in the intron of AVPR1a is associated with trust and reciprocity in humans. Four-hundred and thirty-three participants played the trust game, answered the attitudinal trust question, and their buccal cells were collected. Results showed that men with a short form of AVPR1a tend to send more money to the opponent, even if there is a possibility of being betrayed by the opponent. Additionally, people with a short form of AVPR1a tended to return money to the opponent who trusts them. However, attitudinal trust was not associated with AVPR1a. These results indicate that arginine-vasopressin receptor 1a plays an important role in trust and reciprocal behaviors.https://www.frontiersin.org/article/10.3389/fnhum.2019.00230/fulltrust gametrustreciprocityeconomic gameAVPR1A genegene |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kuniyuki Nishina Haruto Takagishi Hidehiko Takahashi Masamichi Sakagami Miho Inoue-Murayama |
spellingShingle |
Kuniyuki Nishina Haruto Takagishi Hidehiko Takahashi Masamichi Sakagami Miho Inoue-Murayama Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity Frontiers in Human Neuroscience trust game trust reciprocity economic game AVPR1A gene gene |
author_facet |
Kuniyuki Nishina Haruto Takagishi Hidehiko Takahashi Masamichi Sakagami Miho Inoue-Murayama |
author_sort |
Kuniyuki Nishina |
title |
Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity |
title_short |
Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity |
title_full |
Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity |
title_fullStr |
Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity |
title_full_unstemmed |
Association of Polymorphism of Arginine-Vasopressin Receptor 1A (AVPR1a) Gene With Trust and Reciprocity |
title_sort |
association of polymorphism of arginine-vasopressin receptor 1a (avpr1a) gene with trust and reciprocity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2019-07-01 |
description |
Oxytocin (OXT) is known to play an important role in trust, whereas the involvement of other peptide hormones has not been evaluated. In this study, we focused on microsatellite polymorphisms in the intron of the arginine-vasopressin receptor 1a (AVPR1a) gene and examined whether the association between the repeat lengths in the intron of AVPR1a is associated with trust and reciprocity in humans. Four-hundred and thirty-three participants played the trust game, answered the attitudinal trust question, and their buccal cells were collected. Results showed that men with a short form of AVPR1a tend to send more money to the opponent, even if there is a possibility of being betrayed by the opponent. Additionally, people with a short form of AVPR1a tended to return money to the opponent who trusts them. However, attitudinal trust was not associated with AVPR1a. These results indicate that arginine-vasopressin receptor 1a plays an important role in trust and reciprocal behaviors. |
topic |
trust game trust reciprocity economic game AVPR1A gene gene |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2019.00230/full |
work_keys_str_mv |
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