EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS

EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS

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The article presents a case report of severe clinical course of systemic type of juvenile rheumatoid arthritis refractory to the immunosuppressive treatment. The disease was characterized with such extra-articular symptoms as fever, lymphadenopathia, hepatosplenomegaly, polyserositis. Generalized jo...

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Main Authors: S.I. Valieva, E.I. Alexeeva, E.Yu. Gudkova, T.M. Bzarova, K.B. Isaeva, R.V. Denisova, A.O. Lisitsin, T.V. Sleptsova, A.A. Grigor'eva
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2009-11-01
Series:Voprosy Sovremennoj Pediatrii
Online Access:https://vsp.spr-journal.ru/jour/article/view/1197
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spelling doaj-b16be2a57d924eeeaec56866f141d9782021-07-28T21:15:39Zeng"Paediatrician" Publishers LLC Voprosy Sovremennoj Pediatrii1682-55271682-55352009-11-018685911198EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITISS.I. Valieva0E.I. Alexeeva1E.Yu. Gudkova2T.M. Bzarova3K.B. Isaeva4R.V. Denisova5A.O. Lisitsin6T.V. Sleptsova7A.A. Grigor'eva8Scientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowThe article presents a case report of severe clinical course of systemic type of juvenile rheumatoid arthritis refractory to the immunosuppressive treatment. The disease was characterized with such extra-articular symptoms as fever, lymphadenopathia, hepatosplenomegaly, polyserositis. Generalized joints lesion and high laboratory signs of disease’s activity presented. Significant hormone-dependence and hormone-resistance on the ground of corticosteroids developed. Inclusion of rituximab to the scheme of treatment stopped systemic symptoms of a disease, inflammatory lesions in joints, and normalized laboratory rates of activity. Beneficial effect of treatment allowed lowering of peroral corticosteroids’ dose. Obtained results testify to high effectiveness of rituximab. This medication can be the drug of choice in a treatment of children with systemic type of juvenile rheumatoid arthritis, refractory to immunosuppressive therapy and corticosteroids.Key words: children, systemic type of juvenile rheumatoid arthritis, rituximab.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):85-91)https://vsp.spr-journal.ru/jour/article/view/1197
collection DOAJ
language English
format Article
sources DOAJ
author S.I. Valieva
E.I. Alexeeva
E.Yu. Gudkova
T.M. Bzarova
K.B. Isaeva
R.V. Denisova
A.O. Lisitsin
T.V. Sleptsova
A.A. Grigor'eva
spellingShingle S.I. Valieva
E.I. Alexeeva
E.Yu. Gudkova
T.M. Bzarova
K.B. Isaeva
R.V. Denisova
A.O. Lisitsin
T.V. Sleptsova
A.A. Grigor'eva
EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
Voprosy Sovremennoj Pediatrii
author_facet S.I. Valieva
E.I. Alexeeva
E.Yu. Gudkova
T.M. Bzarova
K.B. Isaeva
R.V. Denisova
A.O. Lisitsin
T.V. Sleptsova
A.A. Grigor'eva
author_sort S.I. Valieva
title EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
title_short EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
title_full EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
title_fullStr EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
title_full_unstemmed EFFICACY OF RECURRENT TREATMENT WITH RITUXIMAB IN PATIENT WITH SEVERE REFRACTORY SYSTEMIC TYPE OF JUVENILE RHEUMATOID ARTHRITIS
title_sort efficacy of recurrent treatment with rituximab in patient with severe refractory systemic type of juvenile rheumatoid arthritis
publisher "Paediatrician" Publishers LLC
series Voprosy Sovremennoj Pediatrii
issn 1682-5527
1682-5535
publishDate 2009-11-01
description The article presents a case report of severe clinical course of systemic type of juvenile rheumatoid arthritis refractory to the immunosuppressive treatment. The disease was characterized with such extra-articular symptoms as fever, lymphadenopathia, hepatosplenomegaly, polyserositis. Generalized joints lesion and high laboratory signs of disease’s activity presented. Significant hormone-dependence and hormone-resistance on the ground of corticosteroids developed. Inclusion of rituximab to the scheme of treatment stopped systemic symptoms of a disease, inflammatory lesions in joints, and normalized laboratory rates of activity. Beneficial effect of treatment allowed lowering of peroral corticosteroids’ dose. Obtained results testify to high effectiveness of rituximab. This medication can be the drug of choice in a treatment of children with systemic type of juvenile rheumatoid arthritis, refractory to immunosuppressive therapy and corticosteroids.Key words: children, systemic type of juvenile rheumatoid arthritis, rituximab.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):85-91)
url https://vsp.spr-journal.ru/jour/article/view/1197
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