Comparing Effects of Different Doses of Vancomycin on the Biomarkers of Acute Kidney Injury

• Main Authors: Sepideh Elyasi, Hossein Khalili, Alireza Abdollahi
• Format: Article
• Language: English
• Published: Research Center for Rational Use of Drugs (RCRUD) 2019-12-01
• Series: Journal of Pharmaceutical Care
• Subjects: Vancomycin; Cystatin C; Kidney Injurys; KIM-1
• Online Access: https://jpc.tums.ac.ir/index.php/jpc/article/view/292

Background: Effects of different doses of vancomycin on the renal biomarkers (Cys-C and KIM-1) of acute kidney injury were compared in patients with severe bacterial infections.| Methods: Serum levels of Cys-C, KIM-1 and creatinine and urine level of Cys-C were measured at baseline and every other day in patients receiving different doses (15 mg/kg every 8 or 12h) of vancomycin. Results:  Level of serum Cys-C demonstrated significant increased during vancomycin treatment in both groups. However, there was no significant difference between the groups regarding serum Cys-C level. Urine Cys-C level neither changed significantly within nor between groups during vancomycin treatment. The same results were detected for serum KIM-concentrations. Conclusion: Different doses of vancomycin showed comparable effects on the serum and urine biomarkers of acute kidney injury.