Upconversion superballs for programmable photoactivation of therapeutics

The synthesis of nanoparticles capable of orthogonal photo-activity is complex. Here, the authors report on an assembly process of two distinct nanoparticles into composite nanoparticles as a simple method and report on the application in photodynamic therapy and siRNA delivery in tumour therapy.

Bibliographic Details
Main Authors:	Zhen Zhang, Muthu Kumara Gnanasammandhan Jayakumar, Xiang Zheng, Swati Shikha, Yi Zhang, Akshaya Bansal, Dennis J. J. Poon, Pek Lim Chu, Eugenia L. L. Yeo, Melvin L. K. Chua, Soo Khee Chee, Yong Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12506-w

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spelling	doaj-b18f54c23a8349a6b456d95ddb2e30182021-05-11T11:29:50ZengNature Publishing GroupNature Communications2041-17232019-10-0110111210.1038/s41467-019-12506-wUpconversion superballs for programmable photoactivation of therapeuticsZhen Zhang0Muthu Kumara Gnanasammandhan Jayakumar1Xiang Zheng2Swati Shikha3Yi Zhang4Akshaya Bansal5Dennis J. J. Poon6Pek Lim Chu7Eugenia L. L. Yeo8Melvin L. K. Chua9Soo Khee Chee10Yong Zhang11Faculty of Engineering, Department of Biomedical Engineering, National University of SingaporeFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeDivision of Radiation Oncology, National Cancer Centre SingaporeOncology Academic Program, Duke-NUS Medical SchoolDivision of Medical Sciences, National Cancer Centre SingaporeDivision of Radiation Oncology, National Cancer Centre SingaporeOncology Academic Program, Duke-NUS Medical SchoolFaculty of Engineering, Department of Biomedical Engineering, National University of SingaporeThe synthesis of nanoparticles capable of orthogonal photo-activity is complex. Here, the authors report on an assembly process of two distinct nanoparticles into composite nanoparticles as a simple method and report on the application in photodynamic therapy and siRNA delivery in tumour therapy.https://doi.org/10.1038/s41467-019-12506-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhen Zhang Muthu Kumara Gnanasammandhan Jayakumar Xiang Zheng Swati Shikha Yi Zhang Akshaya Bansal Dennis J. J. Poon Pek Lim Chu Eugenia L. L. Yeo Melvin L. K. Chua Soo Khee Chee Yong Zhang
spellingShingle	Zhen Zhang Muthu Kumara Gnanasammandhan Jayakumar Xiang Zheng Swati Shikha Yi Zhang Akshaya Bansal Dennis J. J. Poon Pek Lim Chu Eugenia L. L. Yeo Melvin L. K. Chua Soo Khee Chee Yong Zhang Upconversion superballs for programmable photoactivation of therapeutics Nature Communications
author_facet	Zhen Zhang Muthu Kumara Gnanasammandhan Jayakumar Xiang Zheng Swati Shikha Yi Zhang Akshaya Bansal Dennis J. J. Poon Pek Lim Chu Eugenia L. L. Yeo Melvin L. K. Chua Soo Khee Chee Yong Zhang
author_sort	Zhen Zhang
title	Upconversion superballs for programmable photoactivation of therapeutics
title_short	Upconversion superballs for programmable photoactivation of therapeutics
title_full	Upconversion superballs for programmable photoactivation of therapeutics
title_fullStr	Upconversion superballs for programmable photoactivation of therapeutics
title_full_unstemmed	Upconversion superballs for programmable photoactivation of therapeutics
title_sort	upconversion superballs for programmable photoactivation of therapeutics
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-10-01
description	The synthesis of nanoparticles capable of orthogonal photo-activity is complex. Here, the authors report on an assembly process of two distinct nanoparticles into composite nanoparticles as a simple method and report on the application in photodynamic therapy and siRNA delivery in tumour therapy.
url	https://doi.org/10.1038/s41467-019-12506-w
work_keys_str_mv	AT zhenzhang upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT muthukumaragnanasammandhanjayakumar upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT xiangzheng upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT swatishikha upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT yizhang upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT akshayabansal upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT dennisjjpoon upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT peklimchu upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT eugeniallyeo upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT melvinlkchua upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT sookheechee upconversionsuperballsforprogrammablephotoactivationoftherapeutics AT yongzhang upconversionsuperballsforprogrammablephotoactivationoftherapeutics
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Upconversion superballs for programmable photoactivation of therapeutics

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