Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms
Malaria, which is caused by <i>Plasmodium</i> parasites through <i>Anopheles</i> mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. <i>Plasmodium vivax</i>, which accounts for the...
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doaj-b197f719d8fc4b2086fb2cf3b0b26b892021-07-23T13:59:40ZengMDPI AGPathogens2076-08172021-07-011088988910.3390/pathogens10070889Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion MechanismsJing-Wen Hang0Farhana Tukijan1Erica-Qian-Hui Lee2Shifana Raja Abdeen3Yaw Aniweh4Benoit Malleret5Immunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117545, SingaporeImmunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117545, SingaporeImmunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117545, SingaporeSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore 138648, SingaporeWest Africa Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, GhanaImmunology Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore 117545, SingaporeMalaria, which is caused by <i>Plasmodium</i> parasites through <i>Anopheles</i> mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. <i>Plasmodium vivax</i>, which accounts for the majority of cases of recurring malaria caused by the <i>Plasmodium</i> (non-<i>Laverania</i>) subgenus, is an ancient and continuing zoonosis originating from monkey hosts probably outside Africa. The emergence of other zoonotic malarias (<i>P. knowlesi</i>, <i>P. cynomolgi</i>, and <i>P. simium</i>) further highlights the seriousness of the disease. The severity of this epidemic disease is dependent on many factors, including the parasite characteristics, host-parasite interactions, and the pathology of the infection. Successful infection depends on the ability of the parasite to invade the host; however, little is known about the parasite invasion biology and mechanisms. The lack of this information adds to the challenges to malaria control and elimination, hence enhancing the potential for continuation of this zoonosis. Here, we review the literature describing the characteristics, distribution, and genome details of the parasites, as well as host specificity, host-parasite interactions, and parasite pathology. This information will provide the basis of a greater understanding of the epidemiology and pathogenesis of malaria to support future development of strategies for the control and prevention of this zoonotic infection.https://www.mdpi.com/2076-0817/10/7/889zoonotic malariahost speciesgenomepathologyinvasion mechanism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing-Wen Hang Farhana Tukijan Erica-Qian-Hui Lee Shifana Raja Abdeen Yaw Aniweh Benoit Malleret |
spellingShingle |
Jing-Wen Hang Farhana Tukijan Erica-Qian-Hui Lee Shifana Raja Abdeen Yaw Aniweh Benoit Malleret Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms Pathogens zoonotic malaria host species genome pathology invasion mechanism |
author_facet |
Jing-Wen Hang Farhana Tukijan Erica-Qian-Hui Lee Shifana Raja Abdeen Yaw Aniweh Benoit Malleret |
author_sort |
Jing-Wen Hang |
title |
Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms |
title_short |
Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms |
title_full |
Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms |
title_fullStr |
Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms |
title_full_unstemmed |
Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms |
title_sort |
zoonotic malaria: non-<i>laverania plasmodium</i> biology and invasion mechanisms |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2021-07-01 |
description |
Malaria, which is caused by <i>Plasmodium</i> parasites through <i>Anopheles</i> mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. <i>Plasmodium vivax</i>, which accounts for the majority of cases of recurring malaria caused by the <i>Plasmodium</i> (non-<i>Laverania</i>) subgenus, is an ancient and continuing zoonosis originating from monkey hosts probably outside Africa. The emergence of other zoonotic malarias (<i>P. knowlesi</i>, <i>P. cynomolgi</i>, and <i>P. simium</i>) further highlights the seriousness of the disease. The severity of this epidemic disease is dependent on many factors, including the parasite characteristics, host-parasite interactions, and the pathology of the infection. Successful infection depends on the ability of the parasite to invade the host; however, little is known about the parasite invasion biology and mechanisms. The lack of this information adds to the challenges to malaria control and elimination, hence enhancing the potential for continuation of this zoonosis. Here, we review the literature describing the characteristics, distribution, and genome details of the parasites, as well as host specificity, host-parasite interactions, and parasite pathology. This information will provide the basis of a greater understanding of the epidemiology and pathogenesis of malaria to support future development of strategies for the control and prevention of this zoonotic infection. |
topic |
zoonotic malaria host species genome pathology invasion mechanism |
url |
https://www.mdpi.com/2076-0817/10/7/889 |
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