A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth

A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth

The c-Myc oncogene is a transcription factor that regulates the expression of a very large set of genes mainly involved in cell growth and proliferation. It is overexpressed in more than 70% of human cancers, illustrating the importance of keeping its levels and activity under control. The ubiquitin...

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Bibliographic Details
Main Authors: Dominique Thevenon, Ilham Seffouh, Catherine Pillet, Xenia Crespo-Yanez, Marie-Odile Fauvarque, Emmanuel Taillebourg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
deubiquitinase (DUB)
ubiquitin (Ub)
MYC stability
CRISPR/Cas9
cell growth
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00506/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00506/full

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