Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum
Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained co...
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doaj-b1a0e309909d45bb9c9f24e8648ee57c2020-11-24T21:33:10ZengMDPI AGMarine Drugs1660-33972018-07-0116722610.3390/md16070226md16070226Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporumJunjun Meng0Wei Cheng1Hajar Heydari2Bin Wang3Kui Zhu4Belma Konuklugil5Wenhan Lin6State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaDepartment of Pharmacoguosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06100, TurkiyeFood and Medicine College, Zhejiang Ocean University, Zhoushan 316022, ChinaCollege of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaDepartment of Pharmacoguosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06100, TurkiyeState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaAntibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A–H (1–8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 μg/mL, while saturnispol H showed selective effects against VRE and B. subtilis.http://www.mdpi.com/1660-3397/16/7/226marine fungusTrichoderma saturnisporumsaturnispols A–Hstructural elucidationantibacterial effects |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junjun Meng Wei Cheng Hajar Heydari Bin Wang Kui Zhu Belma Konuklugil Wenhan Lin |
spellingShingle |
Junjun Meng Wei Cheng Hajar Heydari Bin Wang Kui Zhu Belma Konuklugil Wenhan Lin Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum Marine Drugs marine fungus Trichoderma saturnisporum saturnispols A–H structural elucidation antibacterial effects |
author_facet |
Junjun Meng Wei Cheng Hajar Heydari Bin Wang Kui Zhu Belma Konuklugil Wenhan Lin |
author_sort |
Junjun Meng |
title |
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum |
title_short |
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum |
title_full |
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum |
title_fullStr |
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum |
title_full_unstemmed |
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum |
title_sort |
sorbicillinoid-based metabolites from a sponge-derived fungus trichoderma saturnisporum |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2018-07-01 |
description |
Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A–H (1–8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 μg/mL, while saturnispol H showed selective effects against VRE and B. subtilis. |
topic |
marine fungus Trichoderma saturnisporum saturnispols A–H structural elucidation antibacterial effects |
url |
http://www.mdpi.com/1660-3397/16/7/226 |
work_keys_str_mv |
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