The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

IntroductionPseudoxanthoma elasticum (PXE) is a rare disease caused by mutations in the ABCC6 gene. Vitamin K1 is involved in the posttranslational carboxylation of some proteins related to inhibition of the calcification process. Our aim was to investigate, in patients affected by PXE, baseline lev...

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Bibliographic Details
Main Authors: Juan Luis Carrillo-Linares, María Inmaculada García-Fernández, María José Morillo, Purificación Sánchez, José Rioja, Francisco Javier Barón, María José Ariza, Dominic J. Harrington, David Card, Federica Boraldi, Daniela Quaglino, Pedro Valdivielso
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Medicine
Subjects:
vitamin K
pseudoxanthoma elasticum
carboxylated proteins
osteocalcin
menaquinone
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00086/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00086/full

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