A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection
Fungi that infect insects can potentially be exploited for disease vector control. Here the authors show that the fungus Beauveria bassiana exports a microRNA-like RNA into mosquito cells that modulates host immunity by suppressing expression of Toll receptor ligand Spätzle 4.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12323-1 |
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doaj-b1a618ff0f2441b9a5117839d2cd232d2021-05-11T12:27:51ZengNature Publishing GroupNature Communications2041-17232019-09-0110111010.1038/s41467-019-12323-1A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infectionChunlai Cui0Yan Wang1Jingnan Liu2Jing Zhao3Peilu Sun4Sibao Wang5CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesSchool of Life Science and Technology, ShanghaiTech UniversityCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesFungi that infect insects can potentially be exploited for disease vector control. Here the authors show that the fungus Beauveria bassiana exports a microRNA-like RNA into mosquito cells that modulates host immunity by suppressing expression of Toll receptor ligand Spätzle 4.https://doi.org/10.1038/s41467-019-12323-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chunlai Cui Yan Wang Jingnan Liu Jing Zhao Peilu Sun Sibao Wang |
| spellingShingle |
Chunlai Cui Yan Wang Jingnan Liu Jing Zhao Peilu Sun Sibao Wang A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection Nature Communications |
| author_facet |
Chunlai Cui Yan Wang Jingnan Liu Jing Zhao Peilu Sun Sibao Wang |
| author_sort |
Chunlai Cui |
| title |
A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection |
| title_short |
A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection |
| title_full |
A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection |
| title_fullStr |
A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection |
| title_full_unstemmed |
A fungal pathogen deploys a small silencing RNA that attenuates mosquito immunity and facilitates infection |
| title_sort |
fungal pathogen deploys a small silencing rna that attenuates mosquito immunity and facilitates infection |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
Fungi that infect insects can potentially be exploited for disease vector control. Here the authors show that the fungus Beauveria bassiana exports a microRNA-like RNA into mosquito cells that modulates host immunity by suppressing expression of Toll receptor ligand Spätzle 4. |
| url |
https://doi.org/10.1038/s41467-019-12323-1 |
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