The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas
Mutation of the isocitrate-dehydrogenase (IDH) enzymes is one of the central research topics regarding gliomagenesis. Indeed, 70% of gliomas are associated with a gain-of-function IDH mutation and consequently synthesize the oncometabolite, 2-hydroxyglutarate (2-HG). This review aims to elucidate th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2018-12-01
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| Series: | Contemporary Oncology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/The-effects-of-2-hydroxyglutarate-on-the-tumorigenesis-of-gliomas,3,35744,1,1.html |