Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia.
BACKGROUND:Among immigrants of sub-Saharan origin, parasitic infection is the leading cause of eosinophilia, which is generally interpreted as a defense mechanism. A side effect of the inflammatory mediators released by eosinophils is damage to host organs, especially the heart. The main objectives...
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doaj-b1c31ab684d74c36b1c998c69b0d99472020-11-24T20:45:00ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-02-01112e000540310.1371/journal.pntd.0005403Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia.Cristina Carranza-RodríguezDaniel San-Román-SánchezHéctor Marrero-SantiagoMichele Hernández-CabreraCarlos Gil-GuillénElena Pisos-ÁlamoNieves Jaén-SánchezJosé-Luis Pérez-ArellanoBACKGROUND:Among immigrants of sub-Saharan origin, parasitic infection is the leading cause of eosinophilia, which is generally interpreted as a defense mechanism. A side effect of the inflammatory mediators released by eosinophils is damage to host organs, especially the heart. The main objectives of this study were to i) assess cardiac involvement in asymptomatic sub-Saharan immigrants with eosinophilia, ii) relate the presence of lesions with the degree of eosinophilia, and iii) study the relationship between cardiac involvement and the type of causative parasite. METHODOLOGY/PRINCIPLE FINDINGS:In total, the study included 50 black immigrants (37 patients and 13 controls) from sub-Saharan Africa. In all subjects, heart structure and function were evaluated in a blinded manner using Sonos 5500 echocardiographic equipment. The findings were classified and described according to established criteria. The diagnostic criteria for helminthosis were those reported in the literature. Serum eosinophil-derived neurotoxin levels were measured using enzyme-linked immunosorbent assay. A significant association was found between the presence of eosinophilia and structural alterations (mitral valve thickening). However, the lack of an association between the degree of eosinophilia and heart valve disease and the absence of valve involvement in some patients with eosinophilia suggest the role of other factors in the appearance of endocardial lesions. There was also no association between the type of helminth and valve involvement. CONCLUSIONS:We, therefore, suggest that transthoracic echocardiography be performed in every sub-Saharan individual with eosinophilia in order to rule out early heart valve lesions.http://europepmc.org/articles/PMC5342272?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristina Carranza-Rodríguez Daniel San-Román-Sánchez Héctor Marrero-Santiago Michele Hernández-Cabrera Carlos Gil-Guillén Elena Pisos-Álamo Nieves Jaén-Sánchez José-Luis Pérez-Arellano |
spellingShingle |
Cristina Carranza-Rodríguez Daniel San-Román-Sánchez Héctor Marrero-Santiago Michele Hernández-Cabrera Carlos Gil-Guillén Elena Pisos-Álamo Nieves Jaén-Sánchez José-Luis Pérez-Arellano Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. PLoS Neglected Tropical Diseases |
author_facet |
Cristina Carranza-Rodríguez Daniel San-Román-Sánchez Héctor Marrero-Santiago Michele Hernández-Cabrera Carlos Gil-Guillén Elena Pisos-Álamo Nieves Jaén-Sánchez José-Luis Pérez-Arellano |
author_sort |
Cristina Carranza-Rodríguez |
title |
Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. |
title_short |
Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. |
title_full |
Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. |
title_fullStr |
Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. |
title_full_unstemmed |
Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia. |
title_sort |
endomyocardial involvement in asymptomatic sub-saharan immigrants with helminth-related eosinophilia. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2017-02-01 |
description |
BACKGROUND:Among immigrants of sub-Saharan origin, parasitic infection is the leading cause of eosinophilia, which is generally interpreted as a defense mechanism. A side effect of the inflammatory mediators released by eosinophils is damage to host organs, especially the heart. The main objectives of this study were to i) assess cardiac involvement in asymptomatic sub-Saharan immigrants with eosinophilia, ii) relate the presence of lesions with the degree of eosinophilia, and iii) study the relationship between cardiac involvement and the type of causative parasite. METHODOLOGY/PRINCIPLE FINDINGS:In total, the study included 50 black immigrants (37 patients and 13 controls) from sub-Saharan Africa. In all subjects, heart structure and function were evaluated in a blinded manner using Sonos 5500 echocardiographic equipment. The findings were classified and described according to established criteria. The diagnostic criteria for helminthosis were those reported in the literature. Serum eosinophil-derived neurotoxin levels were measured using enzyme-linked immunosorbent assay. A significant association was found between the presence of eosinophilia and structural alterations (mitral valve thickening). However, the lack of an association between the degree of eosinophilia and heart valve disease and the absence of valve involvement in some patients with eosinophilia suggest the role of other factors in the appearance of endocardial lesions. There was also no association between the type of helminth and valve involvement. CONCLUSIONS:We, therefore, suggest that transthoracic echocardiography be performed in every sub-Saharan individual with eosinophilia in order to rule out early heart valve lesions. |
url |
http://europepmc.org/articles/PMC5342272?pdf=render |
work_keys_str_mv |
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