Ethyl 2-[2-(4-Nitrobenzoyl)-1H-indol-3-yl]acetate

Ethyl 2-[2-(4-nitrobenzoyl)-1H-indol-3-yl]acetate was prepared in good yield and characterized by the aza-alkylation/intramolecular Michael cascade reaction of (E)-ethyl 3-[2-(tosylamino)phenyl]acrylate with 2-bromo-4′′-nitroacetophenone, followed by desulfonative dehydrogenation with 1,8-diazabicyc...

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Bibliographic Details
Main Authors: Sunyoung Choi, Sung-Gon Kim
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molbank
Subjects:
Online Access:https://www.mdpi.com/1422-8599/2017/3/M945
Description
Summary:Ethyl 2-[2-(4-nitrobenzoyl)-1H-indol-3-yl]acetate was prepared in good yield and characterized by the aza-alkylation/intramolecular Michael cascade reaction of (E)-ethyl 3-[2-(tosylamino)phenyl]acrylate with 2-bromo-4′′-nitroacetophenone, followed by desulfonative dehydrogenation with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) The structure of the newly synthesized compound was determined using 1H-,13C-NMR, IR and mass spectral data.
ISSN:1422-8599