IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning
Abstract Background Viral infectious diseases are the serious threat for human health. The receptor-binding is the first step for the viral infection of hosts. To more effectively treat human viral infectious diseases, the hidden virus-receptor interactions must be discovered. However, current compu...
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doaj-b1dd3ca365414767ac9819f286db7fb82020-12-27T12:21:08ZengBMCBMC Bioinformatics1471-21052019-12-0120S231910.1186/s12859-019-3278-3IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learningCheng Yan0Guihua Duan1Fang-Xiang Wu2Jianxin Wang3School of Computer Science and Engineering, Central South UniversitySchool of Computer Science and Engineering, Central South UniversityBiomedical Engineering and Department of Mechanical Engineering, University of SaskatchewanSchool of Computer Science and Engineering, Central South UniversityAbstract Background Viral infectious diseases are the serious threat for human health. The receptor-binding is the first step for the viral infection of hosts. To more effectively treat human viral infectious diseases, the hidden virus-receptor interactions must be discovered. However, current computational methods for predicting virus-receptor interactions are limited. Result In this study, we propose a new computational method (IILLS) to predict virus-receptor interactions based on Initial Interaction scores method via the neighbors and the Laplacian regularized Least Square algorithm. IILLS integrates the known virus-receptor interactions and amino acid sequences of receptors. The similarity of viruses is calculated by the Gaussian Interaction Profile (GIP) kernel. On the other hand, we also compute the receptor GIP similarity and the receptor sequence similarity. Then the sequence similarity is used as the final similarity of receptors according to the prediction results. The 10-fold cross validation (10CV) and leave one out cross validation (LOOCV) are used to assess the prediction performance of our method. We also compare our method with other three competing methods (BRWH, LapRLS, CMF). Conlusion The experiment results show that IILLS achieves the AUC values of 0.8675 and 0.9061 with the 10-fold cross validation and leave-one-out cross validation (LOOCV), respectively, which illustrates that IILLS is superior to the competing methods. In addition, the case studies also further indicate that the IILLS method is effective for the virus-receptor interaction prediction.https://doi.org/10.1186/s12859-019-3278-3Virus-receptor interactionSimilaritySemi-supervised learningLaplacian regularized least squares classifierGaussian interaction profile (GIP) kernel |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cheng Yan Guihua Duan Fang-Xiang Wu Jianxin Wang |
spellingShingle |
Cheng Yan Guihua Duan Fang-Xiang Wu Jianxin Wang IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning BMC Bioinformatics Virus-receptor interaction Similarity Semi-supervised learning Laplacian regularized least squares classifier Gaussian interaction profile (GIP) kernel |
author_facet |
Cheng Yan Guihua Duan Fang-Xiang Wu Jianxin Wang |
author_sort |
Cheng Yan |
title |
IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning |
title_short |
IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning |
title_full |
IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning |
title_fullStr |
IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning |
title_full_unstemmed |
IILLS: predicting virus-receptor interactions based on similarity and semi-supervised learning |
title_sort |
iills: predicting virus-receptor interactions based on similarity and semi-supervised learning |
publisher |
BMC |
series |
BMC Bioinformatics |
issn |
1471-2105 |
publishDate |
2019-12-01 |
description |
Abstract Background Viral infectious diseases are the serious threat for human health. The receptor-binding is the first step for the viral infection of hosts. To more effectively treat human viral infectious diseases, the hidden virus-receptor interactions must be discovered. However, current computational methods for predicting virus-receptor interactions are limited. Result In this study, we propose a new computational method (IILLS) to predict virus-receptor interactions based on Initial Interaction scores method via the neighbors and the Laplacian regularized Least Square algorithm. IILLS integrates the known virus-receptor interactions and amino acid sequences of receptors. The similarity of viruses is calculated by the Gaussian Interaction Profile (GIP) kernel. On the other hand, we also compute the receptor GIP similarity and the receptor sequence similarity. Then the sequence similarity is used as the final similarity of receptors according to the prediction results. The 10-fold cross validation (10CV) and leave one out cross validation (LOOCV) are used to assess the prediction performance of our method. We also compare our method with other three competing methods (BRWH, LapRLS, CMF). Conlusion The experiment results show that IILLS achieves the AUC values of 0.8675 and 0.9061 with the 10-fold cross validation and leave-one-out cross validation (LOOCV), respectively, which illustrates that IILLS is superior to the competing methods. In addition, the case studies also further indicate that the IILLS method is effective for the virus-receptor interaction prediction. |
topic |
Virus-receptor interaction Similarity Semi-supervised learning Laplacian regularized least squares classifier Gaussian interaction profile (GIP) kernel |
url |
https://doi.org/10.1186/s12859-019-3278-3 |
work_keys_str_mv |
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