Acute Hemodialysis for Treatment of Severe Ethanol Intoxication
A male college student presented to the emergency department with altered mental status and a serum ethanol level higher than the hospital laboratory assay. His course was complicated by mechanical ventilation, vasopressors, and cardiotoxicity. Thirteen hours into admission and despite aggressive su...
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2020-11-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059520301862 |
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doaj-b1e0e47dc36f4aa59a5ec5254be5e9fc2020-12-09T04:17:05ZengElsevierKidney Medicine2590-05952020-11-0126793796Acute Hemodialysis for Treatment of Severe Ethanol IntoxicationDevin Driscoll0Griffin Bleecker1Jean Francis2Aala Jaberi3Boston University Medical Center, Boston, MABoston University Medical Center, Boston, MABoston University Medical Center, Boston, MAAddress for Correspondence: Aala Jaberi, MB, BCh, Nephrology Section, Boston University Medical Center, BCD Building, 800 Harrison Avenue, Boston 02118, MA.; Boston University Medical Center, Boston, MAA male college student presented to the emergency department with altered mental status and a serum ethanol level higher than the hospital laboratory assay. His course was complicated by mechanical ventilation, vasopressors, and cardiotoxicity. Thirteen hours into admission and despite aggressive supportive measures, the patient remained obtunded off sedation with serum ethanol level elevated at 428 mg/dL. A decision was made to initiate hemodialysis to expedite ethanol clearance and prevent further end-organ damage. Two hours into hemodialysis, mental status improved and serum ethanol level had decreased to 264 mg/dL. A total of 4 hours of hemodialysis were completed and serum ethanol level continued to downtrend. Dialysis increased the rate of ethanol elimination by a factor of 4 and prevented further cardiotoxicity or electrolyte level abnormalities. This case supports the use of hemodialysis for adult patients who meet the criteria of severe ethanol toxicity requiring critical care resources and having evidence of organ toxicity to 1 or more organ.http://www.sciencedirect.com/science/article/pii/S2590059520301862Ethanol toxicityhemodialysisclearancealtered mental statuscardiotoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Devin Driscoll Griffin Bleecker Jean Francis Aala Jaberi |
spellingShingle |
Devin Driscoll Griffin Bleecker Jean Francis Aala Jaberi Acute Hemodialysis for Treatment of Severe Ethanol Intoxication Kidney Medicine Ethanol toxicity hemodialysis clearance altered mental status cardiotoxicity |
author_facet |
Devin Driscoll Griffin Bleecker Jean Francis Aala Jaberi |
author_sort |
Devin Driscoll |
title |
Acute Hemodialysis for Treatment of Severe Ethanol Intoxication |
title_short |
Acute Hemodialysis for Treatment of Severe Ethanol Intoxication |
title_full |
Acute Hemodialysis for Treatment of Severe Ethanol Intoxication |
title_fullStr |
Acute Hemodialysis for Treatment of Severe Ethanol Intoxication |
title_full_unstemmed |
Acute Hemodialysis for Treatment of Severe Ethanol Intoxication |
title_sort |
acute hemodialysis for treatment of severe ethanol intoxication |
publisher |
Elsevier |
series |
Kidney Medicine |
issn |
2590-0595 |
publishDate |
2020-11-01 |
description |
A male college student presented to the emergency department with altered mental status and a serum ethanol level higher than the hospital laboratory assay. His course was complicated by mechanical ventilation, vasopressors, and cardiotoxicity. Thirteen hours into admission and despite aggressive supportive measures, the patient remained obtunded off sedation with serum ethanol level elevated at 428 mg/dL. A decision was made to initiate hemodialysis to expedite ethanol clearance and prevent further end-organ damage. Two hours into hemodialysis, mental status improved and serum ethanol level had decreased to 264 mg/dL. A total of 4 hours of hemodialysis were completed and serum ethanol level continued to downtrend. Dialysis increased the rate of ethanol elimination by a factor of 4 and prevented further cardiotoxicity or electrolyte level abnormalities. This case supports the use of hemodialysis for adult patients who meet the criteria of severe ethanol toxicity requiring critical care resources and having evidence of organ toxicity to 1 or more organ. |
topic |
Ethanol toxicity hemodialysis clearance altered mental status cardiotoxicity |
url |
http://www.sciencedirect.com/science/article/pii/S2590059520301862 |
work_keys_str_mv |
AT devindriscoll acutehemodialysisfortreatmentofsevereethanolintoxication AT griffinbleecker acutehemodialysisfortreatmentofsevereethanolintoxication AT jeanfrancis acutehemodialysisfortreatmentofsevereethanolintoxication AT aalajaberi acutehemodialysisfortreatmentofsevereethanolintoxication |
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1724388560823386112 |