Prediction of primary somatosensory neuron activity during active tactile exploration
Primary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimot...
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doaj-b1e6ac8d8e8a4b3c8274237ca0811b182021-05-05T00:15:58ZengeLife Sciences Publications LtdeLife2050-084X2016-02-01510.7554/eLife.10696Prediction of primary somatosensory neuron activity during active tactile explorationDario Campagner0https://orcid.org/0000-0001-9016-4575Mathew Hywel Evans1Michael Ross Bale2Andrew Erskine3https://orcid.org/0000-0003-4392-1873Rasmus Strange Petersen4Faculty of Life Sciences, The University of Manchester, Manchester, United KingdomFaculty of Life Sciences, The University of Manchester, Manchester, United KingdomFaculty of Life Sciences, The University of Manchester, Manchester, United Kingdom; School of Life Sciences, University of Sussex, Brighton, United KingdomFaculty of Life Sciences, The University of Manchester, Manchester, United Kingdom; Mill Hill Laboratory, The Francis Crick Institute, London, United KingdomFaculty of Life Sciences, The University of Manchester, Manchester, United KingdomPrimary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimotor integration, we recorded from primary mechanosensory neurons of awake, head-fixed mice as they explored a pole with their whiskers, and simultaneously measured both whisker motion and forces with high-speed videography. Using Generalised Linear Models, we found that primary neuron responses were poorly predicted by whisker angle, but well-predicted by rotational forces acting on the whisker: both during touch and free-air whisker motion. These results are in apparent contrast to previous studies of passive stimulation, but could be reconciled by differences in the kinematics-force relationship between active and passive conditions. Thus, simple statistical models can predict rich neural activity elicited by natural, exploratory behaviour involving active movement of sense organs.https://elifesciences.org/articles/10696neural codingactive sensationwhiskerGeneralized Linear Modeltrigeminal ganglion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dario Campagner Mathew Hywel Evans Michael Ross Bale Andrew Erskine Rasmus Strange Petersen |
spellingShingle |
Dario Campagner Mathew Hywel Evans Michael Ross Bale Andrew Erskine Rasmus Strange Petersen Prediction of primary somatosensory neuron activity during active tactile exploration eLife neural coding active sensation whisker Generalized Linear Model trigeminal ganglion |
author_facet |
Dario Campagner Mathew Hywel Evans Michael Ross Bale Andrew Erskine Rasmus Strange Petersen |
author_sort |
Dario Campagner |
title |
Prediction of primary somatosensory neuron activity during active tactile exploration |
title_short |
Prediction of primary somatosensory neuron activity during active tactile exploration |
title_full |
Prediction of primary somatosensory neuron activity during active tactile exploration |
title_fullStr |
Prediction of primary somatosensory neuron activity during active tactile exploration |
title_full_unstemmed |
Prediction of primary somatosensory neuron activity during active tactile exploration |
title_sort |
prediction of primary somatosensory neuron activity during active tactile exploration |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2016-02-01 |
description |
Primary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimotor integration, we recorded from primary mechanosensory neurons of awake, head-fixed mice as they explored a pole with their whiskers, and simultaneously measured both whisker motion and forces with high-speed videography. Using Generalised Linear Models, we found that primary neuron responses were poorly predicted by whisker angle, but well-predicted by rotational forces acting on the whisker: both during touch and free-air whisker motion. These results are in apparent contrast to previous studies of passive stimulation, but could be reconciled by differences in the kinematics-force relationship between active and passive conditions. Thus, simple statistical models can predict rich neural activity elicited by natural, exploratory behaviour involving active movement of sense organs. |
topic |
neural coding active sensation whisker Generalized Linear Model trigeminal ganglion |
url |
https://elifesciences.org/articles/10696 |
work_keys_str_mv |
AT dariocampagner predictionofprimarysomatosensoryneuronactivityduringactivetactileexploration AT mathewhywelevans predictionofprimarysomatosensoryneuronactivityduringactivetactileexploration AT michaelrossbale predictionofprimarysomatosensoryneuronactivityduringactivetactileexploration AT andrewerskine predictionofprimarysomatosensoryneuronactivityduringactivetactileexploration AT rasmusstrangepetersen predictionofprimarysomatosensoryneuronactivityduringactivetactileexploration |
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1721476536191680512 |