Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds
Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on th...
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doaj-b1ebe05cbd554e8f8e8c676237b3002b2020-11-24T23:58:41ZengMDPI AGMolecules1420-30492013-11-011811143971441310.3390/molecules181114397molecules181114397Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn WoundsŻaneta Jastrzębska-Stojko0Rafał Stojko1Anna Rzepecka-Stojko2Agata Kabała-Dzik3Jerzy Stojko4Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, PolandDepartment of Women Health, School of Health Sciences, Medical University of Silesia in Katowice, Medyków 12, 40-752 Katowice, PolandDepartment of Pharmaceutical Chemistry, School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, PolandDeparment of Pathology School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Ostrogórska 3, 41-200 Sosnowiec, PolandDepartment of Hygiene, Bioanalysis and Environmental Studies School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Kasztanowa 3A, 41-200 Sosnowiec, PolandMedicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.http://www.mdpi.com/1420-3049/18/11/14397propolisbee honeyburn woundcollagenhydroxyproline |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Żaneta Jastrzębska-Stojko Rafał Stojko Anna Rzepecka-Stojko Agata Kabała-Dzik Jerzy Stojko |
spellingShingle |
Żaneta Jastrzębska-Stojko Rafał Stojko Anna Rzepecka-Stojko Agata Kabała-Dzik Jerzy Stojko Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds Molecules propolis bee honey burn wound collagen hydroxyproline |
author_facet |
Żaneta Jastrzębska-Stojko Rafał Stojko Anna Rzepecka-Stojko Agata Kabała-Dzik Jerzy Stojko |
author_sort |
Żaneta Jastrzębska-Stojko |
title |
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds |
title_short |
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds |
title_full |
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds |
title_fullStr |
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds |
title_full_unstemmed |
Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds |
title_sort |
biological activity of propolis-honey balm in the treatment of experimentally-evoked burn wounds |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2013-11-01 |
description |
Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy. |
topic |
propolis bee honey burn wound collagen hydroxyproline |
url |
http://www.mdpi.com/1420-3049/18/11/14397 |
work_keys_str_mv |
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