Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F

Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F

Abstract Background Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin in the extracellular matrix. Overexpression of SSPN ameliorates Duchen...

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Bibliographic Details
Main Authors: Angela K. Peter, Gaynor Miller, Joana Capote, Marino DiFranco, Alhondra Solares-Pérez, Emily L. Wang, Jim Heighway, Ramón M. Coral-Vázquez, Julio Vergara, Rachelle H. Crosbie-Watson
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Skeletal Muscle
Subjects:
Duchenne muscular dystrophy
Dystrophin
Limb girdle muscular dystrophy
Microspan
Nanospan
Sarcolemma
Online Access:http://link.springer.com/article/10.1186/s13395-017-0127-9

Internet

http://link.springer.com/article/10.1186/s13395-017-0127-9

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