Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections

Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections

Abstract Background Thresholds for SARS-CoV-2 antibody assays have typically been determined using samples from symptomatic, often hospitalised, patients. In this setting the sensitivity and specificity of the best performing assays can both exceed 98%. However, antibody assay performance following...

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Bibliographic Details
Main Authors: David W. Eyre, Sheila F. Lumley, Denise O’Donnell, Nicole E. Stoesser, Philippa C. Matthews, Alison Howarth, Stephanie B. Hatch, Brian D. Marsden, Stuart Cox, Tim James, Richard J. Cornall, David I. Stuart, Gavin Screaton, Daniel Ebner, Derrick W. Crook, Christopher P. Conlon, Katie Jeffery, Timothy M. Walker, Timothy E. A. Peto
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Infectious Diseases
Subjects:
SARS-CoV-2
COVID-19
Serology
Antibodies
Anosmia
Ageusia
Online Access:https://doi.org/10.1186/s12879-021-05878-2

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