Maternal Programming of Social Dominance via Milk Cytokines
Summary: Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/...
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doaj-b1f84f2de7644b85a679f468b4abd94d2020-11-25T03:56:13ZengElsevieriScience2589-00422020-08-01238101357Maternal Programming of Social Dominance via Milk CytokinesFaten Taki0Katherine Lopez1Bojana Zupan2Paul Bergin3Melissa D. Docampo4Michele Alves-Bezerra5Judit Gal Toth6Qiuying Chen7Kimon V. Argyropoulos8Luendreo Barboza9Emily Pickup10Nicholas Fancher11Abbi Hiller12Steven Gross13David E. Cohen14Marcel R.M. van den Brink15Miklos Toth16Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USAPsychological Science Department, Vassar College, Poughkeepsie 124 Raymond Avenue, New York, NY 12604, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADepartments of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USADivision of Gastroenterology and Hepatology, Weill Department of Medicine, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADepartments of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USAPsychological Science Department, Vassar College, Poughkeepsie 124 Raymond Avenue, New York, NY 12604, USAPsychological Science Department, Vassar College, Poughkeepsie 124 Raymond Avenue, New York, NY 12604, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USADivision of Gastroenterology and Hepatology, Weill Department of Medicine, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USADepartments of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USADepartment of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA; Corresponding authorSummary: Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/metabolic health, of their otherwise sedentary offspring. The individual's own physical activity did not improve dominance status. Maternal exercise did not disrupt maternal care or the maternal and offspring microbiota. Rather, the development of dominance behavior in the offspring of running mothers could be explained by the reduction of LIF, CXCL1, and CXCL2 cytokines in breast milk. These data reveal a cytokine-mediated lactocrine pathway that responds to the mother's postpartum physical activity and programs offspring social dominance. As dominance behaviors are highly relevant to the individual's survival and reproduction, lactocrine programming could be an evolutionary mechanism by which a mother promotes the social rank of her offspring.http://www.sciencedirect.com/science/article/pii/S2589004220305447Biological SciencesBehavioral NeuroscienceImmunology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Faten Taki Katherine Lopez Bojana Zupan Paul Bergin Melissa D. Docampo Michele Alves-Bezerra Judit Gal Toth Qiuying Chen Kimon V. Argyropoulos Luendreo Barboza Emily Pickup Nicholas Fancher Abbi Hiller Steven Gross David E. Cohen Marcel R.M. van den Brink Miklos Toth |
spellingShingle |
Faten Taki Katherine Lopez Bojana Zupan Paul Bergin Melissa D. Docampo Michele Alves-Bezerra Judit Gal Toth Qiuying Chen Kimon V. Argyropoulos Luendreo Barboza Emily Pickup Nicholas Fancher Abbi Hiller Steven Gross David E. Cohen Marcel R.M. van den Brink Miklos Toth Maternal Programming of Social Dominance via Milk Cytokines iScience Biological Sciences Behavioral Neuroscience Immunology |
author_facet |
Faten Taki Katherine Lopez Bojana Zupan Paul Bergin Melissa D. Docampo Michele Alves-Bezerra Judit Gal Toth Qiuying Chen Kimon V. Argyropoulos Luendreo Barboza Emily Pickup Nicholas Fancher Abbi Hiller Steven Gross David E. Cohen Marcel R.M. van den Brink Miklos Toth |
author_sort |
Faten Taki |
title |
Maternal Programming of Social Dominance via Milk Cytokines |
title_short |
Maternal Programming of Social Dominance via Milk Cytokines |
title_full |
Maternal Programming of Social Dominance via Milk Cytokines |
title_fullStr |
Maternal Programming of Social Dominance via Milk Cytokines |
title_full_unstemmed |
Maternal Programming of Social Dominance via Milk Cytokines |
title_sort |
maternal programming of social dominance via milk cytokines |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2020-08-01 |
description |
Summary: Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/metabolic health, of their otherwise sedentary offspring. The individual's own physical activity did not improve dominance status. Maternal exercise did not disrupt maternal care or the maternal and offspring microbiota. Rather, the development of dominance behavior in the offspring of running mothers could be explained by the reduction of LIF, CXCL1, and CXCL2 cytokines in breast milk. These data reveal a cytokine-mediated lactocrine pathway that responds to the mother's postpartum physical activity and programs offspring social dominance. As dominance behaviors are highly relevant to the individual's survival and reproduction, lactocrine programming could be an evolutionary mechanism by which a mother promotes the social rank of her offspring. |
topic |
Biological Sciences Behavioral Neuroscience Immunology |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220305447 |
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