Nutrient and Metabolic Sensing in T Cell Responses
T cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T cell responses by impinging upon T cell fates and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00247/full |
| id |
doaj-b20a4632d2c74a5e864c72ed6fe0e87b |
|---|---|
| record_format |
Article |
| spelling |
doaj-b20a4632d2c74a5e864c72ed6fe0e87b2020-11-24T21:44:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-03-01810.3389/fimmu.2017.00247252690Nutrient and Metabolic Sensing in T Cell ResponsesJun Wei0Jana Raynor1Thanh-Long M. Nguyen2Hongbo Chi3Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USAT cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T cell responses by impinging upon T cell fates and immune functions. In this review, we summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors and transporters shape T cell responses. We also briefly discuss regulation of T cell responses by oxygen and energy sensing mechanisms.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00247/fullglucoseamino acidlipidoxygenenergyT cell response |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jun Wei Jana Raynor Thanh-Long M. Nguyen Hongbo Chi |
| spellingShingle |
Jun Wei Jana Raynor Thanh-Long M. Nguyen Hongbo Chi Nutrient and Metabolic Sensing in T Cell Responses Frontiers in Immunology glucose amino acid lipid oxygen energy T cell response |
| author_facet |
Jun Wei Jana Raynor Thanh-Long M. Nguyen Hongbo Chi |
| author_sort |
Jun Wei |
| title |
Nutrient and Metabolic Sensing in T Cell Responses |
| title_short |
Nutrient and Metabolic Sensing in T Cell Responses |
| title_full |
Nutrient and Metabolic Sensing in T Cell Responses |
| title_fullStr |
Nutrient and Metabolic Sensing in T Cell Responses |
| title_full_unstemmed |
Nutrient and Metabolic Sensing in T Cell Responses |
| title_sort |
nutrient and metabolic sensing in t cell responses |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2017-03-01 |
| description |
T cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T cell responses by impinging upon T cell fates and immune functions. In this review, we summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors and transporters shape T cell responses. We also briefly discuss regulation of T cell responses by oxygen and energy sensing mechanisms. |
| topic |
glucose amino acid lipid oxygen energy T cell response |
| url |
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00247/full |
| work_keys_str_mv |
AT junwei nutrientandmetabolicsensingintcellresponses AT janaraynor nutrientandmetabolicsensingintcellresponses AT thanhlongmnguyen nutrientandmetabolicsensingintcellresponses AT hongbochi nutrientandmetabolicsensingintcellresponses |
| _version_ |
1725909115080802304 |