Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases
Objective The purpose of this article was to provide a combined pathologic and radiologic review of previous pathologically diagnosed facial nerve “hemangiomas” to confirm that these lesions are most characteristic of venous malformations rather than neoplasms. Study Design Retrospective radiologic,...
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doaj-b20b680a07d14f278c013ea66616b77d2020-11-25T02:59:57ZengWileyLaryngoscope Investigative Otolaryngology2378-80382019-06-014334735210.1002/lio2.267Facial nerve venous malformation: A radiologic and histopathologic review of 11 casesJulie B. Guerin0Edwin A. Takahashi1John I. Lane2Joseph M. Hoxworth3Steven M. Weindling4Melissa M. Blessing5Mark E. Jentoft6Matthew L. Carlson7Brian A. Neff8Christopher P. Wood9Department of Radiology Mayo Clinic Rochester MinnesotaDepartment of Radiology Mayo Clinic Rochester MinnesotaDepartment of Radiology Mayo Clinic Rochester MinnesotaDepartment of Radiology Mayo Clinic Hospital Phoenix ArizonaDepartment of Radiology Mayo Clinic Jacksonville FloridaDepartment of Laboratory Medicine and Pathology Mayo Clinic Rochester MinnesotaDepartment of Laboratory Medicine and Pathology Mayo Clinic Jacksonville FloridaDepartment of Otorhinolaryngology—Head and Neck Surgery Mayo Clinic Rochester MinnesotaDepartment of Otorhinolaryngology—Head and Neck Surgery Mayo Clinic Rochester MinnesotaDepartment of Radiology Mayo Clinic Rochester MinnesotaObjective The purpose of this article was to provide a combined pathologic and radiologic review of previous pathologically diagnosed facial nerve “hemangiomas” to confirm that these lesions are most characteristic of venous malformations rather than neoplasms. Study Design Retrospective radiologic, clinical, and histopathologic review of all patients with a previous pathologically diagnosed facial nerve hemangioma of the temporal bone who underwent computed tomography or magnetic resonance imaging (MRI) were included. A consensus radiologic review for characteristic features and pathologic analysis was performed. Materials and Methods A panel of 4 neuroradiologists retrospectively analyzed CT and MRI exams for 11 facial nerve hemangiomas and provided a consensus agreement on the characteristic imaging features. Concurrently, two neuropathologists reevaluated archived tissue specimens from these lesions and applied additional immunohistochemical and histochemical stains including D240, CD31, smooth muscle actin (SMA), Verhoeff Van Gieson (VVG) and glucose transporter 1 (GLUT1). Results Lesions were composed of dilated vascular spaces with a simple, CD31‐positive endothelial lining and a smooth muscle component. All lesions were negative for markers found in arterial and lymphatic malformations and infantile hemangiomas. They had characteristic radiologic features previously ascribed to facial nerve hemangiomas. Namely, these lesions are typically T1 isointense or hypointense and T2 hyperintense relative to cerebral cortex and heterogeneously enhance on MRI. Bony canal expansion and erosion, intralesional calcification, and intracranial extension are common. Conclusions On the basis of this radiologic and pathologic review, these lesions are best characterized as venous malformations. Level of Evidence 4https://doi.org/10.1002/lio2.267Facial nervegeniculate hemangiomatemporal bonevenous malformation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie B. Guerin Edwin A. Takahashi John I. Lane Joseph M. Hoxworth Steven M. Weindling Melissa M. Blessing Mark E. Jentoft Matthew L. Carlson Brian A. Neff Christopher P. Wood |
spellingShingle |
Julie B. Guerin Edwin A. Takahashi John I. Lane Joseph M. Hoxworth Steven M. Weindling Melissa M. Blessing Mark E. Jentoft Matthew L. Carlson Brian A. Neff Christopher P. Wood Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases Laryngoscope Investigative Otolaryngology Facial nerve geniculate hemangioma temporal bone venous malformation |
author_facet |
Julie B. Guerin Edwin A. Takahashi John I. Lane Joseph M. Hoxworth Steven M. Weindling Melissa M. Blessing Mark E. Jentoft Matthew L. Carlson Brian A. Neff Christopher P. Wood |
author_sort |
Julie B. Guerin |
title |
Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases |
title_short |
Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases |
title_full |
Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases |
title_fullStr |
Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases |
title_full_unstemmed |
Facial nerve venous malformation: A radiologic and histopathologic review of 11 cases |
title_sort |
facial nerve venous malformation: a radiologic and histopathologic review of 11 cases |
publisher |
Wiley |
series |
Laryngoscope Investigative Otolaryngology |
issn |
2378-8038 |
publishDate |
2019-06-01 |
description |
Objective The purpose of this article was to provide a combined pathologic and radiologic review of previous pathologically diagnosed facial nerve “hemangiomas” to confirm that these lesions are most characteristic of venous malformations rather than neoplasms. Study Design Retrospective radiologic, clinical, and histopathologic review of all patients with a previous pathologically diagnosed facial nerve hemangioma of the temporal bone who underwent computed tomography or magnetic resonance imaging (MRI) were included. A consensus radiologic review for characteristic features and pathologic analysis was performed. Materials and Methods A panel of 4 neuroradiologists retrospectively analyzed CT and MRI exams for 11 facial nerve hemangiomas and provided a consensus agreement on the characteristic imaging features. Concurrently, two neuropathologists reevaluated archived tissue specimens from these lesions and applied additional immunohistochemical and histochemical stains including D240, CD31, smooth muscle actin (SMA), Verhoeff Van Gieson (VVG) and glucose transporter 1 (GLUT1). Results Lesions were composed of dilated vascular spaces with a simple, CD31‐positive endothelial lining and a smooth muscle component. All lesions were negative for markers found in arterial and lymphatic malformations and infantile hemangiomas. They had characteristic radiologic features previously ascribed to facial nerve hemangiomas. Namely, these lesions are typically T1 isointense or hypointense and T2 hyperintense relative to cerebral cortex and heterogeneously enhance on MRI. Bony canal expansion and erosion, intralesional calcification, and intracranial extension are common. Conclusions On the basis of this radiologic and pathologic review, these lesions are best characterized as venous malformations. Level of Evidence 4 |
topic |
Facial nerve geniculate hemangioma temporal bone venous malformation |
url |
https://doi.org/10.1002/lio2.267 |
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