Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma
ObjectiveAdjuvant radiotherapy is the main treatment modality for high grade meningioma after surgical resection; however, recurrence and survival outcomes vary. The aim of this study was to create a new “prognostic score” that allows personalized recommendations for post-operative adjuvant radiothe...
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doaj-b2129e7943e345e0ad9b77e1b6e2ab212020-11-25T04:10:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.568079568079Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade MeningiomaDaijun Wang0Shuchen Sun1Lingyang Hua2Jiaojiao Deng3Shihai Luan4Haixia Cheng5Qing Xie6Hiroaki Wakimoto7Hongda Zhu8Ye Gong9Ye Gong10Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neuropathology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Critical Care Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaObjectiveAdjuvant radiotherapy is the main treatment modality for high grade meningioma after surgical resection; however, recurrence and survival outcomes vary. The aim of this study was to create a new “prognostic score” that allows personalized recommendations for post-operative adjuvant radiotherapy in patients with high grade meningioma.MethodsClinical data were collected from 115 patients with high grade meningioma treated with surgical resection and adjuvant radiotherapy. A prognostic model was built based on the hazards ratios of independent prognostic factors yielded by multivariate cox proportional analysis. Calibration and discrimination of the prognostic score was evaluated using good of fit test and Harrel’s C index, respectively.ResultsA total of 115 high grade meningioma patients (72 atypical and 43 anaplastic meningiomas) were enrolled. Three factors were independently associated with progression-free survival (PFS): extent of resection (GTR vs. STR), recurrent status (de novo vs. recurrent), and Ki-67 labeling index (<5% vs. ≥ 5%). The respective β-coefficients were used to generate the “prognostic score”. The cohort was divided into low-risk and high-risk groups based on the median prognostic score. Good of fit test showed strong calibration (P = 0.7133) and Harrel’s C index 0.766 indicated a strong discrimination capability of the prognostic score. The Harrel’s C index for OS was 0.60.ConclusionsOur prognostic model using three basic clinical parameters robustly separated high grade meningioma patients who benefit vs. do not benefit from adjuvant radiotherapy. External validation of our model is warranted to help improve patient selection suitable for adjuvant radiotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2020.568079/fullhigh grade meningiomaprognostic modelradiationprognosisatypical meningiomaanaplastic meningioma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daijun Wang Shuchen Sun Lingyang Hua Jiaojiao Deng Shihai Luan Haixia Cheng Qing Xie Hiroaki Wakimoto Hongda Zhu Ye Gong Ye Gong |
spellingShingle |
Daijun Wang Shuchen Sun Lingyang Hua Jiaojiao Deng Shihai Luan Haixia Cheng Qing Xie Hiroaki Wakimoto Hongda Zhu Ye Gong Ye Gong Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma Frontiers in Oncology high grade meningioma prognostic model radiation prognosis atypical meningioma anaplastic meningioma |
author_facet |
Daijun Wang Shuchen Sun Lingyang Hua Jiaojiao Deng Shihai Luan Haixia Cheng Qing Xie Hiroaki Wakimoto Hongda Zhu Ye Gong Ye Gong |
author_sort |
Daijun Wang |
title |
Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma |
title_short |
Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma |
title_full |
Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma |
title_fullStr |
Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma |
title_full_unstemmed |
Prognostic Model That Predicts Benefits of Adjuvant Radiotherapy in Patients With High Grade Meningioma |
title_sort |
prognostic model that predicts benefits of adjuvant radiotherapy in patients with high grade meningioma |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-11-01 |
description |
ObjectiveAdjuvant radiotherapy is the main treatment modality for high grade meningioma after surgical resection; however, recurrence and survival outcomes vary. The aim of this study was to create a new “prognostic score” that allows personalized recommendations for post-operative adjuvant radiotherapy in patients with high grade meningioma.MethodsClinical data were collected from 115 patients with high grade meningioma treated with surgical resection and adjuvant radiotherapy. A prognostic model was built based on the hazards ratios of independent prognostic factors yielded by multivariate cox proportional analysis. Calibration and discrimination of the prognostic score was evaluated using good of fit test and Harrel’s C index, respectively.ResultsA total of 115 high grade meningioma patients (72 atypical and 43 anaplastic meningiomas) were enrolled. Three factors were independently associated with progression-free survival (PFS): extent of resection (GTR vs. STR), recurrent status (de novo vs. recurrent), and Ki-67 labeling index (<5% vs. ≥ 5%). The respective β-coefficients were used to generate the “prognostic score”. The cohort was divided into low-risk and high-risk groups based on the median prognostic score. Good of fit test showed strong calibration (P = 0.7133) and Harrel’s C index 0.766 indicated a strong discrimination capability of the prognostic score. The Harrel’s C index for OS was 0.60.ConclusionsOur prognostic model using three basic clinical parameters robustly separated high grade meningioma patients who benefit vs. do not benefit from adjuvant radiotherapy. External validation of our model is warranted to help improve patient selection suitable for adjuvant radiotherapy. |
topic |
high grade meningioma prognostic model radiation prognosis atypical meningioma anaplastic meningioma |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.568079/full |
work_keys_str_mv |
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