Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patient...

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Main Authors: Silmara Cristiane da Silveira Andreoli, Nina Jardim Gasparini, Gisele Pereira de Carvalho, Bernardo Garicochea, Robert Edward Pogue, Rosângela Vieira de Andrade
Format: Article
Language:English
Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein
Series:Einstein (São Paulo)
Subjects:
MicroRNAs
Marcadores biológicos
Neoplasias colorretais/quimioterapia
Resultado de tratamento
Terapia combinada
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=en
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spelling doaj-b21e63ff896145e7ba1557a4a83706872020-11-24T21:51:18ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638512225625810.1590/S1679-45082014MD2839S1679-45082014000200256Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancerSilmara Cristiane da Silveira AndreoliNina Jardim GaspariniGisele Pereira de CarvalhoBernardo GaricocheaRobert Edward PogueRosângela Vieira de AndradeColorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=enMicroRNAsMarcadores biológicosNeoplasias colorretais/quimioterapiaResultado de tratamentoTerapia combinada
collection DOAJ
language English
format Article
sources DOAJ
author Silmara Cristiane da Silveira Andreoli
Nina Jardim Gasparini
Gisele Pereira de Carvalho
Bernardo Garicochea
Robert Edward Pogue
Rosângela Vieira de Andrade
spellingShingle Silmara Cristiane da Silveira Andreoli
Nina Jardim Gasparini
Gisele Pereira de Carvalho
Bernardo Garicochea
Robert Edward Pogue
Rosângela Vieira de Andrade
Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
Einstein (São Paulo)
MicroRNAs
Marcadores biológicos
Neoplasias colorretais/quimioterapia
Resultado de tratamento
Terapia combinada
author_facet Silmara Cristiane da Silveira Andreoli
Nina Jardim Gasparini
Gisele Pereira de Carvalho
Bernardo Garicochea
Robert Edward Pogue
Rosângela Vieira de Andrade
author_sort Silmara Cristiane da Silveira Andreoli
title Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_short Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_fullStr Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full_unstemmed Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_sort use of micrornas in directing therapy and evaluating treatment response in colorectal cancer
publisher Instituto Israelita de Ensino e Pesquisa Albert Einstein
series Einstein (São Paulo)
issn 2317-6385
description Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
topic MicroRNAs
Marcadores biológicos
Neoplasias colorretais/quimioterapia
Resultado de tratamento
Terapia combinada
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=en
work_keys_str_mv AT silmaracristianedasilveiraandreoli useofmicrornasindirectingtherapyandevaluatingtreatmentresponseincolorectalcancer
AT ninajardimgasparini useofmicrornasindirectingtherapyandevaluatingtreatmentresponseincolorectalcancer
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