Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

The molecular pathways underlying tumor suppression are incompletely understood. Here, we identify cooperative non-cell-autonomous functions of a single gene that together provide a novel mechanism of tumor suppression in basal keratinocytes of zebrafish embryos. A loss-of-function mutation in atp1b...

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Bibliographic Details
Main Authors: Julia Hatzold, Filippo Beleggia, Hannah Herzig, Janine Altmüller, Peter Nürnberg, Wilhelm Bloch, Bernd Wollnik, Matthias Hammerschmidt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
basal cell carcinogenesis
Na/K-ATPase
epithelial polarity
Online Access:https://elifesciences.org/articles/14277

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