Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either healthy or cancerous tissues by single-shot mass-s...

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Bibliographic Details
Main Authors: Chiara Francavilla, Michela Lupia, Kalliopi Tsafou, Alessandra Villa, Katarzyna Kowalczyk, Rosa Rakownikow Jersie-Christensen, Giovanni Bertalot, Stefano Confalonieri, Søren Brunak, Lars J. Jensen, Ugo Cavallaro, Jesper V. Olsen
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
ovarian cancer
quantitative proteomics
phosphoproteomics
CDK7
POLR2A
alternative splicing
EOC
fimbriae
OSE
THZ1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303327

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http://www.sciencedirect.com/science/article/pii/S2211124717303327

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