Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment
Loss of white matter (WM) integrity contributes to subcortical vascular mild cognitive impairment (svMCI). Diffusion tensor imaging (DTI) has revealed damage beyond the area of WM hyperintensity (WMH) including in normal-appearing WM (NAWM); however, the functional significance of this observation i...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-02-01
|
Series: | Frontiers in Aging Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.605900/full |
id |
doaj-b23a80e1d02d4f22ae28b934c2ddfff1 |
---|---|
record_format |
Article |
spelling |
doaj-b23a80e1d02d4f22ae28b934c2ddfff12021-02-18T06:35:22ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-02-011310.3389/fnagi.2021.605900605900Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive ImpairmentYage Qiu0Ling Yu1Xin Ge2Yawen Sun3Yao Wang4Xiaowei Wu5Qun Xu6Qun Xu7Yan Zhou8Jianrong Xu9Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Health Manage Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaLoss of white matter (WM) integrity contributes to subcortical vascular mild cognitive impairment (svMCI). Diffusion tensor imaging (DTI) has revealed damage beyond the area of WM hyperintensity (WMH) including in normal-appearing WM (NAWM); however, the functional significance of this observation is unclear. To answer this question, in this study we investigated the relationship between microstructural changes in the WMH penumbra (WMH-P) and cognitive function in patients with svMCI by regional tract-based analysis. A total of 111 patients with svMCI and 72 patients with subcortical ischemic vascular disease (SIVD) without cognitive impairment (controls) underwent DTI and neuropsychological assessment. WMH burden was determined before computing mean values of fractional anisotropy (FA) and mean diffusivity (MD) within WMHs and WMH-Ps. Pearson’s partial correlations were used to assess the relationship between measurements showing significant intergroup differences and composite Z-scores representing global cognitive function. Multiple linear regression analysis was carried out to determine the best model for predicting composite Z-scores. We found that WMH burden in the genu, body, and splenium of the corpus callosum (GCC, BCC, and SCC respectively); bilateral anterior, superior, and posterior corona radiata; left sagittal stratum was significantly higher in the svMCI group than in the control group (p < 0.05). The WMH burden of the GCC, BCC, SCC, and bilateral anterior corona radiata was negatively correlated with composite Z-scores. Among diffusion parameters showing significant differences across the 10 WM regions, mean FA values of WMH and WMH-P of the BCC were correlated with composite Z-scores in svMCI patients. The results of the multiple linear regression analysis showed that the FA of WMH-P of the BCC and WMH burden of the SCC and GCC were independent predictors of composite Z-score, with the FA of WMH-P of the BCC making the largest contribution. These findings indicate that disruption of the CC microstructure—especially the WMH-P of the BCC—may contribute to the cognitive deficits associated with SIVD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.605900/fullsubcortical vascular mild cognitive impairmentwhite matter hyperintensitiesnormal-appearing white matterpenumbradiffusion tensor imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yage Qiu Ling Yu Xin Ge Yawen Sun Yao Wang Xiaowei Wu Qun Xu Qun Xu Yan Zhou Jianrong Xu |
spellingShingle |
Yage Qiu Ling Yu Xin Ge Yawen Sun Yao Wang Xiaowei Wu Qun Xu Qun Xu Yan Zhou Jianrong Xu Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment Frontiers in Aging Neuroscience subcortical vascular mild cognitive impairment white matter hyperintensities normal-appearing white matter penumbra diffusion tensor imaging |
author_facet |
Yage Qiu Ling Yu Xin Ge Yawen Sun Yao Wang Xiaowei Wu Qun Xu Qun Xu Yan Zhou Jianrong Xu |
author_sort |
Yage Qiu |
title |
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment |
title_short |
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment |
title_full |
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment |
title_fullStr |
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment |
title_full_unstemmed |
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment |
title_sort |
loss of integrity of corpus callosum white matter hyperintensity penumbra predicts cognitive decline in patients with subcortical vascular mild cognitive impairment |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-02-01 |
description |
Loss of white matter (WM) integrity contributes to subcortical vascular mild cognitive impairment (svMCI). Diffusion tensor imaging (DTI) has revealed damage beyond the area of WM hyperintensity (WMH) including in normal-appearing WM (NAWM); however, the functional significance of this observation is unclear. To answer this question, in this study we investigated the relationship between microstructural changes in the WMH penumbra (WMH-P) and cognitive function in patients with svMCI by regional tract-based analysis. A total of 111 patients with svMCI and 72 patients with subcortical ischemic vascular disease (SIVD) without cognitive impairment (controls) underwent DTI and neuropsychological assessment. WMH burden was determined before computing mean values of fractional anisotropy (FA) and mean diffusivity (MD) within WMHs and WMH-Ps. Pearson’s partial correlations were used to assess the relationship between measurements showing significant intergroup differences and composite Z-scores representing global cognitive function. Multiple linear regression analysis was carried out to determine the best model for predicting composite Z-scores. We found that WMH burden in the genu, body, and splenium of the corpus callosum (GCC, BCC, and SCC respectively); bilateral anterior, superior, and posterior corona radiata; left sagittal stratum was significantly higher in the svMCI group than in the control group (p < 0.05). The WMH burden of the GCC, BCC, SCC, and bilateral anterior corona radiata was negatively correlated with composite Z-scores. Among diffusion parameters showing significant differences across the 10 WM regions, mean FA values of WMH and WMH-P of the BCC were correlated with composite Z-scores in svMCI patients. The results of the multiple linear regression analysis showed that the FA of WMH-P of the BCC and WMH burden of the SCC and GCC were independent predictors of composite Z-score, with the FA of WMH-P of the BCC making the largest contribution. These findings indicate that disruption of the CC microstructure—especially the WMH-P of the BCC—may contribute to the cognitive deficits associated with SIVD. |
topic |
subcortical vascular mild cognitive impairment white matter hyperintensities normal-appearing white matter penumbra diffusion tensor imaging |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.605900/full |
work_keys_str_mv |
AT yageqiu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT lingyu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT xinge lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT yawensun lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT yaowang lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT xiaoweiwu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT qunxu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT qunxu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT yanzhou lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment AT jianrongxu lossofintegrityofcorpuscallosumwhitematterhyperintensitypenumbrapredictscognitivedeclineinpatientswithsubcorticalvascularmildcognitiveimpairment |
_version_ |
1724263807133417472 |