Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)

Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inh...

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Main Authors:	Yu-Chia Chang, Tsong-Long Hwang, Liang-Mou Kuo, Ping-Jyun Sung
Format:	Article
Language:	English
Published:	MDPI AG 2017-01-01
Series:	Marine Drugs
Subjects:	9,11-secosterol gorgonian Pinnigorgia cytotoxicity hepatic stellate cell line (HSC-T6) anti-inflammatory superoxide anion elastase
Online Access:	http://www.mdpi.com/1660-3397/15/1/11

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spelling	doaj-b24522b5bcc84e8b9a184fec26de13342020-11-24T21:33:59ZengMDPI AGMarine Drugs1660-33972017-01-011511110.3390/md15010011md15010011Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)Yu-Chia Chang0Tsong-Long Hwang1Liang-Mou Kuo2Ping-Jyun Sung3National Museum of Marine Biology & Aquarium, Pingtung 944, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanNational Museum of Marine Biology & Aquarium, Pingtung 944, TaiwanSeven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.http://www.mdpi.com/1660-3397/15/1/119,11-secosterolgorgonianPinnigorgiacytotoxicityhepatic stellate cell line (HSC-T6)anti-inflammatorysuperoxide anionelastase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu-Chia Chang Tsong-Long Hwang Liang-Mou Kuo Ping-Jyun Sung
spellingShingle	Yu-Chia Chang Tsong-Long Hwang Liang-Mou Kuo Ping-Jyun Sung Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae) Marine Drugs 9,11-secosterol gorgonian Pinnigorgia cytotoxicity hepatic stellate cell line (HSC-T6) anti-inflammatory superoxide anion elastase
author_facet	Yu-Chia Chang Tsong-Long Hwang Liang-Mou Kuo Ping-Jyun Sung
author_sort	Yu-Chia Chang
title	Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_short	Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_full	Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_fullStr	Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_full_unstemmed	Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_sort	pinnisterols d–j, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral pinnigorgia sp. (gorgoniidae)
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2017-01-01
description	Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.
topic	9,11-secosterol gorgonian Pinnigorgia cytotoxicity hepatic stellate cell line (HSC-T6) anti-inflammatory superoxide anion elastase
url	http://www.mdpi.com/1660-3397/15/1/11
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Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)

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