The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins, and LRRC8, pannexins have minimal sequence sim...

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Bibliographic Details
Main Authors: Kevin Michalski, Johanna L Syrjanen, Erik Henze, Julia Kumpf, Hiro Furukawa, Toshimitsu Kawate
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
pannexin
heptameric channel
ATP release
extracellular loop
ion selectivity
carbenoxolone
Online Access:https://elifesciences.org/articles/54670

Internet

https://elifesciences.org/articles/54670

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