Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines

The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deox...

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Main Authors:	Zuraini Ahmad, Yang Mooi Lim, Gwendoline Cheng Lian Ee, Siau Hui Mah, Soek Sin Teh
Format:	Article
Language:	English
Published:	MDPI AG 2013-02-01
Series:	Molecules
Subjects:	cytotoxicity Mesua beccariana Mesua ferrea Mesua congestiflora structure-activity relationship xanthones
Online Access:	http://www.mdpi.com/1420-3049/18/2/1985

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spelling	doaj-b24d281914e24501a724d9056d6047b42020-11-24T22:24:44ZengMDPI AGMolecules1420-30492013-02-011821985199410.3390/molecules18021985Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell LinesZuraini AhmadYang Mooi LimGwendoline Cheng Lian EeSiau Hui MahSoek Sin TehThe cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.http://www.mdpi.com/1420-3049/18/2/1985cytotoxicityMesua beccarianaMesua ferreaMesua congestiflorastructure-activity relationshipxanthones
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zuraini Ahmad Yang Mooi Lim Gwendoline Cheng Lian Ee Siau Hui Mah Soek Sin Teh
spellingShingle	Zuraini Ahmad Yang Mooi Lim Gwendoline Cheng Lian Ee Siau Hui Mah Soek Sin Teh Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines Molecules cytotoxicity Mesua beccariana Mesua ferrea Mesua congestiflora structure-activity relationship xanthones
author_facet	Zuraini Ahmad Yang Mooi Lim Gwendoline Cheng Lian Ee Siau Hui Mah Soek Sin Teh
author_sort	Zuraini Ahmad
title	Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
title_short	Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
title_full	Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
title_fullStr	Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
title_full_unstemmed	Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
title_sort	cytotoxicity and structure-activity relationships of xanthone derivatives from mesua beccariana, mesua ferrea and mesua congestiflora towards nine human cancer cell lines
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2013-02-01
description	The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
topic	cytotoxicity Mesua beccariana Mesua ferrea Mesua congestiflora structure-activity relationship xanthones
url	http://www.mdpi.com/1420-3049/18/2/1985
work_keys_str_mv	AT zurainiahmad cytotoxicityandstructureactivityrelationshipsofxanthonederivativesfrommesuabeccarianamesuaferreaandmesuacongestifloratowardsninehumancancercelllines AT yangmooilim cytotoxicityandstructureactivityrelationshipsofxanthonederivativesfrommesuabeccarianamesuaferreaandmesuacongestifloratowardsninehumancancercelllines AT gwendolinechenglianee cytotoxicityandstructureactivityrelationshipsofxanthonederivativesfrommesuabeccarianamesuaferreaandmesuacongestifloratowardsninehumancancercelllines AT siauhuimah cytotoxicityandstructureactivityrelationshipsofxanthonederivativesfrommesuabeccarianamesuaferreaandmesuacongestifloratowardsninehumancancercelllines AT soeksinteh cytotoxicityandstructureactivityrelationshipsofxanthonederivativesfrommesuabeccarianamesuaferreaandmesuacongestifloratowardsninehumancancercelllines
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Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines

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