Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

Taking berberine (BBR) as the lead, 23 new BBR derivatives were synthesized and examined for their antiviral activities against four different genotype enterovirus 71 (EV71) strains with a cytopathic effect (CPE) assay. Structure-activity relationship (SAR) studies indicated that introduction of a s...

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Bibliographic Details
Main Authors: Yan-Xiang Wang, Lu Yang, Hui-Qiang Wang, Xiao-Qiang Zhao, Ting Liu, Ying-Hong Li, Qing-Xuan Zeng, Yu-Huan Li, Dan-Qing Song
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
enterovirus 71
berberine
structure-activity relationship
MEK/ERK pathway
autophagy
Online Access:http://www.mdpi.com/1420-3049/23/8/2084

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