EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER

• Main Authors: Fatima Qaiser, Abdul Khaliq Naveed, Sarah Sadiq, Palvasha Waheed, Iqbal Muhammad, Rubina Younis, Shoaib Naiyar Hashmi
• Format: Article
• Language: English
• Published: Khyber Medical University 2015-07-01
• Series: Khyber Medical University Journal
• Online Access: https://www.kmuj.kmu.edu.pk/article/view/14651
• ISSN: 2305-2643; 2305-2651

Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. χ 2  tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α Results: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p<0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p<0.0001). Conclusion: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.