EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER

Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast ca...

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Main Authors:	Fatima Qaiser, Abdul Khaliq Naveed, Sarah Sadiq, Palvasha Waheed, Iqbal Muhammad, Rubina Younis, Shoaib Naiyar Hashmi
Format:	Article
Language:	English
Published:	Khyber Medical University 2015-07-01
Series:	Khyber Medical University Journal
Online Access:	https://www.kmuj.kmu.edu.pk/article/view/14651

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record_format	Article
spelling	doaj-b24fc61dcfd1426e8a9a2c869ce995612020-11-25T01:30:56ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512015-07-0172535914651EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCERFatima Qaiser0Abdul Khaliq Naveed1Sarah SadiqPalvasha WaheedIqbal MuhammadRubina YounisShoaib Naiyar HashmiArmy Medical College, National University of Sciences and TechnologyShoaib Naiyar Hashmi5Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. χ 2 tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α Results: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p<0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p<0.0001). Conclusion: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.https://www.kmuj.kmu.edu.pk/article/view/14651
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fatima Qaiser Abdul Khaliq Naveed Sarah Sadiq Palvasha Waheed Iqbal Muhammad Rubina Younis Shoaib Naiyar Hashmi
spellingShingle	Fatima Qaiser Abdul Khaliq Naveed Sarah Sadiq Palvasha Waheed Iqbal Muhammad Rubina Younis Shoaib Naiyar Hashmi EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER Khyber Medical University Journal
author_facet	Fatima Qaiser Abdul Khaliq Naveed Sarah Sadiq Palvasha Waheed Iqbal Muhammad Rubina Younis Shoaib Naiyar Hashmi
author_sort	Fatima Qaiser
title	EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER
title_short	EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER
title_full	EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER
title_fullStr	EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER
title_full_unstemmed	EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER
title_sort	expression analysis and relationship of protein kinase ck2α with histopathological features in human breast cancer
publisher	Khyber Medical University
series	Khyber Medical University Journal
issn	2305-2643 2305-2651
publishDate	2015-07-01
description	Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. χ 2 tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α Results: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p<0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p<0.0001). Conclusion: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.
url	https://www.kmuj.kmu.edu.pk/article/view/14651
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EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER

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