PlGF knockdown attenuates hypoxia-induced stimulation of cell proliferation and glycolysis of lung adenocarcinoma through inhibiting Wnt/β-catenin pathway

PlGF knockdown attenuates hypoxia-induced stimulation of cell proliferation and glycolysis of lung adenocarcinoma through inhibiting Wnt/β-catenin pathway

Abstract Background Angiogenic placental growth factor (PlGF) plays a role in hypoxia-induced angiogenesis. Here, we aimed to investigate the biological roles of PlGF in cell proliferation and glycolysis of lung adenocarcinoma (LUAD) and the underlying molecular mechanisms. Methods PlGF was knocked...

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Bibliographic Details
Main Authors: Wei Zhang, Yanwei Zhang, Wensheng Zhou, Fangfei Qian, Minjuan Hu, Ya Chen, Jun Lu, Yuqing Lou, Baohui Han
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
Hypoxia
Cell proliferation
Glycolysis
β-catenin
C-myc
Online Access:https://doi.org/10.1186/s12935-020-01714-w

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