Overexpression of 12/15-Lipoxygenase, an Ortholog of Human 15-Lipoxygenase-1, in the Prostate Tumors of TRAMP Mice

Overexpression of 12/15-Lipoxygenase, an Ortholog of Human 15-Lipoxygenase-1, in the Prostate Tumors of TRAMP Mice

Changes in the expression and activity of lipidmetabolizing enzymes, including the linoleic acid (LA) -metabolizing enzyme 15-lipoxygenase-1 (15-LO-1), may play a role in the development and progression of human prostate carcinoma (PCa). We reported that human 15-LO-1 (designated as leukocyte type...

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Bibliographic Details
Main Authors: Uddhav P. Kelavkar, Wayne Glasgow, Sandra J. Olson, Barbara A. Foster, Scott B. Shappell
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Lipoxygenase
prostate cancer
mouse model
TRAMP
linoleic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800150

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