Nitric Oxide and Respiratory Helminthic Diseases
Nitric oxide (NO) is a very simple molecule that displays very important functions both in helminths (mainly those involved in respiratory pathology) and in mammalian hosts. In this paper we review four issues related to interaction of NO and lung helminthic diseases. Firstly, we evaluated data avai...
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Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/2010/958108 |
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doaj-b259ef9f6e1849b999bc2b4013d3e9542020-11-24T21:44:26ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/958108958108Nitric Oxide and Respiratory Helminthic DiseasesAntonio Muro0José-Luís Pérez-Arellano1Laboratorio de Inmunología Parasitaria y Molecular, Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca (CIETUS), Campus Miguel de Unamuno s/n, 37007 Salamanca, SpainUnidad de Enfermedades Infecciosas y Medicina Tropical, Servicio de Medicina Interna, Hospital Universitario de Las Palmas de Gran Canaria, Facultad de Medicina, Universidad de las Palmas de Gran Canaria, 35080 Las Palmas de Gran Canaria, SpainNitric oxide (NO) is a very simple molecule that displays very important functions both in helminths (mainly those involved in respiratory pathology) and in mammalian hosts. In this paper we review four issues related to interaction of NO and lung helminthic diseases. Firstly, we evaluated data available on the NO synthesis and release by helminths and their biological role. Next, we summarized the effect of antigens obtained from different phases of the biological cycle on NO production by host mammalian cells (mainly from human sources). Thirdly, we revised the evaluation of NO on the biological activities and/or the viability of respiratory helminths. Lastly, the deleterious consequences of increased production of NO during helminthic human infection are detailed.http://dx.doi.org/10.1155/2010/958108 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio Muro José-Luís Pérez-Arellano |
spellingShingle |
Antonio Muro José-Luís Pérez-Arellano Nitric Oxide and Respiratory Helminthic Diseases Journal of Biomedicine and Biotechnology |
author_facet |
Antonio Muro José-Luís Pérez-Arellano |
author_sort |
Antonio Muro |
title |
Nitric Oxide and Respiratory Helminthic Diseases |
title_short |
Nitric Oxide and Respiratory Helminthic Diseases |
title_full |
Nitric Oxide and Respiratory Helminthic Diseases |
title_fullStr |
Nitric Oxide and Respiratory Helminthic Diseases |
title_full_unstemmed |
Nitric Oxide and Respiratory Helminthic Diseases |
title_sort |
nitric oxide and respiratory helminthic diseases |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2010-01-01 |
description |
Nitric oxide (NO) is a very simple molecule that displays very important functions both in helminths (mainly those involved in respiratory pathology) and in mammalian hosts. In this paper we review four issues related to interaction of NO and lung helminthic diseases. Firstly, we evaluated data available on the NO synthesis and release by helminths and their biological role. Next, we summarized the effect of antigens obtained from different phases of the biological cycle on NO production by host mammalian cells (mainly from human sources). Thirdly, we revised the evaluation of NO on the biological activities and/or the viability of respiratory helminths. Lastly, the deleterious consequences of increased production of NO during helminthic human infection are detailed. |
url |
http://dx.doi.org/10.1155/2010/958108 |
work_keys_str_mv |
AT antoniomuro nitricoxideandrespiratoryhelminthicdiseases AT joseluisperezarellano nitricoxideandrespiratoryhelminthicdiseases |
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