Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells

Recent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions b...

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Main Authors:	Shyam A. Patel, Andrew C. Heinrich, Bobby Y. Reddy, Balaji Srinivas, Nicole Heidaran, Pranela Rameshwar
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	Journal of Oncology
Online Access:	http://dx.doi.org/10.1155/2008/425895

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spelling	doaj-b25a6f58ac0d41c580c40d24f0567e972020-11-24T20:58:38ZengHindawi LimitedJournal of Oncology1687-84501687-84692008-01-01200810.1155/2008/425895425895Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem CellsShyam A. Patel0Andrew C. Heinrich1Bobby Y. Reddy2Balaji Srinivas3Nicole Heidaran4Pranela Rameshwar5Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USARecent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions between breast cancer cells and cells of the bone marrow. This is a subject of intense research studies aim to provide new methods of treatments and perhaps the identification of new drug targets. This review also discusses the role of inflammation and the bimodal function of the transforming growth factor-𝛽 signaling pathway in the process of tumorigenesis. We bring attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology. Finally, we discuss the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions.http://dx.doi.org/10.1155/2008/425895
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar
spellingShingle	Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells Journal of Oncology
author_facet	Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar
author_sort	Shyam A. Patel
title	Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
title_short	Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
title_full	Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
title_fullStr	Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
title_full_unstemmed	Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
title_sort	breast cancer biology: the multifaceted roles of mesenchymal stem cells
publisher	Hindawi Limited
series	Journal of Oncology
issn	1687-8450 1687-8469
publishDate	2008-01-01
description	Recent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions between breast cancer cells and cells of the bone marrow. This is a subject of intense research studies aim to provide new methods of treatments and perhaps the identification of new drug targets. This review also discusses the role of inflammation and the bimodal function of the transforming growth factor-𝛽 signaling pathway in the process of tumorigenesis. We bring attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology. Finally, we discuss the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions.
url	http://dx.doi.org/10.1155/2008/425895
work_keys_str_mv	AT shyamapatel breastcancerbiologythemultifacetedrolesofmesenchymalstemcells AT andrewcheinrich breastcancerbiologythemultifacetedrolesofmesenchymalstemcells AT bobbyyreddy breastcancerbiologythemultifacetedrolesofmesenchymalstemcells AT balajisrinivas breastcancerbiologythemultifacetedrolesofmesenchymalstemcells AT nicoleheidaran breastcancerbiologythemultifacetedrolesofmesenchymalstemcells AT pranelarameshwar breastcancerbiologythemultifacetedrolesofmesenchymalstemcells
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Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells

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