Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
Recent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions b...
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doaj-b25a6f58ac0d41c580c40d24f0567e972020-11-24T20:58:38ZengHindawi LimitedJournal of Oncology1687-84501687-84692008-01-01200810.1155/2008/425895425895Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem CellsShyam A. Patel0Andrew C. Heinrich1Bobby Y. Reddy2Balaji Srinivas3Nicole Heidaran4Pranela Rameshwar5Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USADivision of Hematology and Oncology, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USARecent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions between breast cancer cells and cells of the bone marrow. This is a subject of intense research studies aim to provide new methods of treatments and perhaps the identification of new drug targets. This review also discusses the role of inflammation and the bimodal function of the transforming growth factor-𝛽 signaling pathway in the process of tumorigenesis. We bring attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology. Finally, we discuss the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions.http://dx.doi.org/10.1155/2008/425895 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar |
spellingShingle |
Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells Journal of Oncology |
author_facet |
Shyam A. Patel Andrew C. Heinrich Bobby Y. Reddy Balaji Srinivas Nicole Heidaran Pranela Rameshwar |
author_sort |
Shyam A. Patel |
title |
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells |
title_short |
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells |
title_full |
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells |
title_fullStr |
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells |
title_full_unstemmed |
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells |
title_sort |
breast cancer biology: the multifaceted roles of mesenchymal stem cells |
publisher |
Hindawi Limited |
series |
Journal of Oncology |
issn |
1687-8450 1687-8469 |
publishDate |
2008-01-01 |
description |
Recent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions between breast cancer cells and cells of the bone marrow. This is a subject of intense research studies aim to provide new methods of treatments and perhaps the identification of new drug targets. This review also discusses the role of inflammation and the bimodal function of the transforming growth factor-𝛽 signaling pathway in the process of tumorigenesis. We bring attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology. Finally, we discuss the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions. |
url |
http://dx.doi.org/10.1155/2008/425895 |
work_keys_str_mv |
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