Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confer...

Full description

Bibliographic Details
Main Authors: Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
tumor microenvironment
immune escape
metabolism
vitamin b
immunotherapy
cd8+ t cells
dendritic cells
survival
cervical cancer
non-small cell lung cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1950954
Description
Summary:Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.
ISSN:2162-402X

Similar Items