Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confer...

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Main Authors:	Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Series:	OncoImmunology
Subjects:	tumor microenvironment immune escape metabolism vitamin b immunotherapy cd8+ t cells dendritic cells survival cervical cancer non-small cell lung cancer
Online Access:	http://dx.doi.org/10.1080/2162402X.2021.1950954

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spelling	doaj-b2687f3d74364dbca677d284bbc182ce2021-07-15T13:10:34ZengTaylor & Francis GroupOncoImmunology2162-402X2021-01-0110110.1080/2162402X.2021.19509541950954Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancersAdrien Joseph0Juncheng Pan1Judith Michels2Guido Kroemer3Maria Castedo4Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des CordeliersUniversité de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des CordeliersGustave Roussy Cancer CampusUniversité de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des CordeliersUniversité de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des CordeliersMalignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.http://dx.doi.org/10.1080/2162402X.2021.1950954tumor microenvironmentimmune escapemetabolismvitamin bimmunotherapycd8+ t cellsdendritic cellssurvivalcervical cancernon-small cell lung cancer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Adrien Joseph Juncheng Pan Judith Michels Guido Kroemer Maria Castedo
spellingShingle	Adrien Joseph Juncheng Pan Judith Michels Guido Kroemer Maria Castedo Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers OncoImmunology tumor microenvironment immune escape metabolism vitamin b immunotherapy cd8+ t cells dendritic cells survival cervical cancer non-small cell lung cancer
author_facet	Adrien Joseph Juncheng Pan Judith Michels Guido Kroemer Maria Castedo
author_sort	Adrien Joseph
title	Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
title_short	Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
title_full	Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
title_fullStr	Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
title_full_unstemmed	Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
title_sort	pyridoxal kinase and poly(adp-ribose) affect the immune microenvironment of locally advanced cancers
publisher	Taylor & Francis Group
series	OncoImmunology
issn	2162-402X
publishDate	2021-01-01
description	Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.
topic	tumor microenvironment immune escape metabolism vitamin b immunotherapy cd8+ t cells dendritic cells survival cervical cancer non-small cell lung cancer
url	http://dx.doi.org/10.1080/2162402X.2021.1950954
work_keys_str_mv	AT adrienjoseph pyridoxalkinaseandpolyadpriboseaffecttheimmunemicroenvironmentoflocallyadvancedcancers AT junchengpan pyridoxalkinaseandpolyadpriboseaffecttheimmunemicroenvironmentoflocallyadvancedcancers AT judithmichels pyridoxalkinaseandpolyadpriboseaffecttheimmunemicroenvironmentoflocallyadvancedcancers AT guidokroemer pyridoxalkinaseandpolyadpriboseaffecttheimmunemicroenvironmentoflocallyadvancedcancers AT mariacastedo pyridoxalkinaseandpolyadpriboseaffecttheimmunemicroenvironmentoflocallyadvancedcancers
_version_	1721300824698650624

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

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