Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confer...
Main Authors: | Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2021-01-01
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Series: | OncoImmunology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/2162402X.2021.1950954 |
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